Regulatory B cells in human autoimmune diseases
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- MIYAGAKI Tomomitsu
- Department of Dermatology, Faculty of Medicine, University of Tokyo
Bibliographic Information
- Other Title
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- 自己免疫疾患における制御性B細胞
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Abstract
B cells have been generally considered to be positive regulators of immune responses because of their ability to produce antigen-specific antibodies and to activate T cells through antigen presentation. Impairment of B cell development and function may cause autoimmune diseases. Recently, specific B cell subsets that can negatively regulate immune responses have been described in mouse models of a wide variety of autoimmune diseases. The concept of those B cells, termed regulatory B cells, is now recognized as important in the murine immune system. Among several regulatory B cell subsets, IL-10-producing regulatory B cells are the most widely investigated. On the basis of discoveries from studies of such mice, human regulatory B cells that produce IL-10 in most cases are becoming an active area of research. There have been emerging data suggesting the importance of human regulatory B cells in various diseases. Revealing the immune regulation mechanisms of human regulatory B cells in human autoimmune diseases could lead to the development of novel B cell targeted therapies. This review highlights the current knowledge on regulatory B cells, mainly IL-10-producing regulatory B cells, in clinical research using human samples.
Journal
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- Japanese Journal of Clinical Immunology
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Japanese Journal of Clinical Immunology 38 (5), 390-397, 2015
The Japan Society for Clinical Immunology