術前内照射および化学療法が著効し,根治切除し得た巨大異所性褐色細胞腫の1例  [in Japanese] A case report of giant ectopic pheochromocytoma conversion therapy with radioisotope therapy and chemotherapy followed by curative resection  [in Japanese]

Access this Article

Author(s)

    • 安井 和也 Yasui Kazuya
    • 岡山大学大学院医歯薬学総合研究科 消化器外科学 Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • 楳田 祐三 Umeda Yuzo
    • 岡山大学大学院医歯薬学総合研究科 消化器外科学 Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • 熊野 健二郎 [他] Kumano Kenjiro
    • 岡山大学大学院医歯薬学総合研究科 消化器外科学 Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • 田端 雅弘 Tabata Masahiro
    • 岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 Department of Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • 大塚 文男 Otsuka Fumio
    • 岡山大学大学院医歯薬学総合研究科 総合内科学 Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • 八木 孝仁 Yagi Takahito
    • 岡山大学大学院医歯薬学総合研究科 消化器外科学 Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • 藤原 俊義 Fujiwara Toshiyoshi
    • 岡山大学大学院医歯薬学総合研究科 消化器外科学 Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Abstract

  A 46-year-old man was found to be positive for occult blood at a medical checkup and was revealed to have a 14-cm tumor on the right side of abdominal aorta by a subsequent abdominal CT scan. The endocrinology laboratory data showed elevations in the levels of serum noradrenaline, and ectopic pheochromocytoma was suspected.<br>  The tumor was compressing the inferior vena cava and portal vein, the superior mesenteric artery and the pancreas. Since it would be difficult to cure by operation, neoadjuvant therapy was started using radioisotope therapy by I-131 metaiodobenzylguanidine (131I-MIBG) and chemotherapy (CVD therapy ; cyclophosphamide, vincristine, dacarbazine). He was treated with three courses of radioisotope therapy and 16 courses of chemotherapy, which significantly reduced the tumor size. This made radical resection possible ; we were able to avoid the merger excision of great vessels and other organs.<br>  On pathological and immunopathological findings, the tumor was diagnosed as ectopic pheochromocytoma. Regarding the safety and curability of the treatment, neoadjuvant therapy may be useful in treating very large tumors that show invasion of other organs.

  A 46-year-old man was found to be positive for occult blood at a medical checkup and was revealed to have a 14-cm tumor on the right side of abdominal aorta by a subsequent abdominal CT scan. The endocrinology laboratory data showed elevations in the levels of serum noradrenaline, and ectopic pheochromocytoma was suspected.<br>  The tumor was compressing the inferior vena cava and portal vein, the superior mesenteric artery and the pancreas. Since it would be difficult to cure by operation, neoadjuvant therapy was started using radioisotope therapy by I-131 metaiodobenzylguanidine (131I-MIBG) and chemotherapy (CVD therapy ; cyclophosphamide, vincristine, dacarbazine). He was treated with three courses of radioisotope therapy and 16 courses of chemotherapy, which significantly reduced the tumor size. This made radical resection possible ; we were able to avoid the merger excision of great vessels and other organs.<br>  On pathological and immunopathological findings, the tumor was diagnosed as ectopic pheochromocytoma. Regarding the safety and curability of the treatment, neoadjuvant therapy may be useful in treating very large tumors that show invasion of other organs.

Journal

  • Okayama Igakkai Zasshi (Journal of Okayama Medical Association)

    Okayama Igakkai Zasshi (Journal of Okayama Medical Association) 127(3), 213-218, 2015

    Okayama Medical Association

Codes

  • NII Article ID (NAID)
    130005116814
  • NII NACSIS-CAT ID (NCID)
    AN00032489
  • Text Lang
    JPN
  • Article Type
    journal article
  • Journal Type
    大学紀要
  • ISSN
    0030-1558
  • NDL Article ID
    026999126
  • NDL Call No.
    Z19-269
  • Data Source
    NDL  IR  J-STAGE 
Page Top