A case report of giant ectopic pheochromocytoma conversion therapy with radioisotope therapy and chemotherapy followed by curative resection

• Yasui Kazuya

  Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Umeda Yuzo

  Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Kumano Kenjiro

  Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Tabata Masahiro

  Department of Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Otsuka Fumio

  Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Yagi Takahito

  Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Fujiwara Toshiyoshi

  Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Bibliographic Information

Other Title

• 術前内照射および化学療法が著効し,根治切除し得た巨大異所性褐色細胞腫の1例
• 症例報告 術前内照射および化学療法が著効し,根治切除し得た巨大異所性褐色細胞腫の1例
• ショウレイ ホウコク ジュツゼン ナイ ショウシャ オヨビ カガク リョウホウ ガ チョコウシ,コンジ セツジョ シエタ キョダイイショセイ カッショク サイボウ シュ ノ 1レイ

Abstract

  A 46-year-old man was found to be positive for occult blood at a medical checkup and was revealed to have a 14-cm tumor on the right side of abdominal aorta by a subsequent abdominal CT scan. The endocrinology laboratory data showed elevations in the levels of serum noradrenaline, and ectopic pheochromocytoma was suspected.<br>   The tumor was compressing the inferior vena cava and portal vein, the superior mesenteric artery and the pancreas. Since it would be difficult to cure by operation, neoadjuvant therapy was started using radioisotope therapy by I-131 metaiodobenzylguanidine (131I-MIBG) and chemotherapy (CVD therapy ; cyclophosphamide, vincristine, dacarbazine). He was treated with three courses of radioisotope therapy and 16 courses of chemotherapy, which significantly reduced the tumor size. This made radical resection possible ; we were able to avoid the merger excision of great vessels and other organs.<br>   On pathological and immunopathological findings, the tumor was diagnosed as ectopic pheochromocytoma. Regarding the safety and curability of the treatment, neoadjuvant therapy may be useful in treating very large tumors that show invasion of other organs.

Journal

• Okayama Igakkai Zasshi (Journal of Okayama Medical Association)

  Okayama Igakkai Zasshi (Journal of Okayama Medical Association) 127 (3), 213-218, 2015

  Okayama Medical Association

Keywords

• ectopic pheochromocytoma
• chemo therapy
• ¹³¹I-MIBG

Details

• CRID: 1390282679851421312
• NII Article ID: 130005116814
• NII Book ID: AN00032489
• DOI: 10.4044/joma.127.213
• ISSN: 18824528
• ISSN: 00301558
• NDL BIB ID: 026999126
• Web Site: https://ousar.lib.okayama-u.ac.jp/53744
• Web Site: http://id.ndl.go.jp/bib/026999126
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026999126
• Web Site: https://www.jstage.jst.go.jp/article/joma/127/3/127_213/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016120584
• Text Lang: ja
• Data Source:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed