Cronkhite-Canada Syndrome with Complete Remission after Four Months of Prednisolone Therapy and Polypectomy

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  • Namikawa Hiroki
    Department of Medical Education and General Practice, Osaka City University, Graduate School of Medicine
  • Takemoto Yasuhiko
    Department of Medical Education and General Practice, Osaka City University, Graduate School of Medicine
  • Kamata Noriko
    Department of Medical Education and General Practice, Osaka City University, Graduate School of Medicine Department of Gastroenterology, Osaka City University, Graduate School of Medicine
  • Yashiro Masakazu
    Department of Surgical Oncology, Oncology Institute of Geriatrics and Medical Science, Osaka City University, Graduate School of Medicine
  • Hirohashi Kazuhiro
    Higashi Sumiyoshi Morimoto Hospital
  • Shuto Taichi
    Department of Medical Education and General Practice, Osaka City University, Graduate School of Medicine

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  • Cronkhite‐Canada Syndrome with Complete Remission after Four Months of Prednisolone Therapy and Polypectomy

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Abstract

The etiology of and optimal treatments for Cronkhite-Canada syndrome (CCS) are still undetermined. Fewer than 5% of CCS patients experience complete remission and 15% of CCS patients develop malignancies. Here, we present a case of CCS involving autoimmune disorders, in which rapid diagnosis, rapid commencement of therapy, and complete remission were achieved after 4 months of prednisolone therapy and polypectomy, although biopsy specimens from all residual colonic polyps revealed adenocarcinoma in one polyp 4 months after prednisolone therapy. It is important to identify gastrointestinal or colonic polyps harboring malignant changes and to examine the involvement of autoimmune mechanisms for better outcomes in CCS patients.

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