From migration to settlement: the pathways, migration modes and dynamics of neurons in the developing brain

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抄録

Neuronal migration is crucial for the construction of the nervous system. To reach their correct destination, migrating neurons choose pathways using physical substrates and chemical cues of either diffusible or non-diffusible nature. Migrating neurons extend a leading and a trailing process. The leading process, which extends in the direction of migration, determines navigation, in particular when a neuron changes its direction of migration. While most neurons simply migrate radially, certain neurons switch their mode of migration between radial and tangential, with the latter allowing migration to destinations far from the neurons' site of generation. Consequently, neurons with distinct origins are intermingled, which results in intricate neuronal architectures and connectivities and provides an important basis for higher brain function. The trailing process, in contrast, contributes to the late stage of development by turning into the axon, thus contributing to the formation of neuronal circuits.

収録刊行物

  • Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences

    Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences 92(1), 1-19, 2016

    日本学士院

各種コード

  • NII論文ID(NAID)
    130005118553
  • NII書誌ID(NCID)
    AA00785485
  • 本文言語コード
    ENG
  • ISSN
    0386-2208
  • NDL 記事登録ID
    027076684
  • NDL 請求記号
    Z53-T495
  • データ提供元
    NDL  J-STAGE 
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