Machine Learning of DTI Structural Brain Connectomes for Lateralization of Temporal Lobe Epilepsy
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- KAMIYA Kouhei
- Department of Radiology, The University of Tokyo
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- AMEMIYA Shiori
- Department of Radiology, The University of Tokyo
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- SUZUKI Yuichi
- Department of Radiological Technology, The University of Tokyo Hospital
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- KUNII Naoto
- Department of Neurosurgery, The University of Tokyo
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- KAWAI Kensuke
- Department of Neurosurgery, NTT Medical Center Tokyo
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- MORI Harushi
- Department of Radiology, The University of Tokyo
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- KUNIMATSU Akira
- Department of Radiology, The University of Tokyo
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- SAITO Nobuhito
- Department of Neurosurgery, The University of Tokyo
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- AOKI Shigeki
- Department of Radiology, Juntendo University School of Medicine
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- OHTOMO Kuni
- Department of Radiology, The University of Tokyo
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抄録
Background and Purpose: We analyzed the ability of a machine learning approach that uses diffusion tensor imaging (DTI) structural connectomes to determine lateralization of epileptogenicity in temporal lobe epilepsy (TLE).<br/>Materials and Methods: We analyzed diffusion tensor and 3-dimensional (3D) T1-weighted images of 44 patients with TLE (right, 15, left, 29; mean age, 33.0 ± 11.6 years) and 14 age-matched controls. We constructed a whole brain structural connectome for each subject, calculated graph theoretical network measures, and used a support vector machine (SVM) for classification among 3 groups (right TLE versus controls, left TLE versus controls, and right TLE versus left TLE) following a feature reduction process with sparse linear regression.<br/>Results: In left TLE, we found a significant decrease in local efficiency and the clustering coefficient in several brain regions, including the left posterior cingulate gyrus, left cuneus, and both hippocampi. In right TLE, the right hippocampus showed reduced nodal degree, clustering coefficient, and local efficiency. With use of the leave-one-out cross-validation strategy, the SVM classifier achieved accuracy of 75.9 to 89.7% for right TLE versus controls, 74.4 to 86.0% for left TLE versus controls, and 72.7 to 86.4% for left TLE versus right TLE.<br/>Conclusion: Machine learning of graph theoretical measures from the DTI structural connectome may give support to lateralization of the TLE focus. The present good discrimination between left and right TLE suggests that, with further refinement, the classifier should improve presurgical diagnostic confidence.
収録刊行物
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- Magnetic Resonance in Medical Sciences
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Magnetic Resonance in Medical Sciences 15 (1), 121-129, 2016
日本磁気共鳴医学会