TET2 Mutation in Adult T-Cell Leukemia/Lymphoma

• Shimoda Kazuya

• Shide Kotaro

• Kameda Takuro

• Hidaka Tomonori

• Kubuki Yoko

• Kamiunten Ayako

• Sekine Masaaki

• Akizuki Keiichi

• Shimoda Haruko

• Yamaji Takumi

• Nakamura Kenichi

• Abe Hiroo

• Miike Tadashi

• Iwakiri Hisayoshi

• Tahara Yoshihiro

• Sueta Mitsue

• Yamamoto Shojiro

• Hasuike Satoru

• Nagata Kenji

• Kitanaka Akira

Abstract

Loss-of-function of ten-eleven translocation-2 (TET2) is a common event in myeloid malignancies, and plays pleiotropic roles, including augmenting stem cell self-renewal and skewing hematopoietic cells to the myeloid lineage. TET2 mutation has also been reported in lymphoid malignancies; 5.7～12% of diffuse large B-cell lymphomas and 18～83% of angioimmunoblastic T-cell lymphomas had TET2 mutations. We investigated TET2 mutations in 22 adult T-cell leukemia/lymphoma (ATLL) patients and identified a missense mutation in 3 cases (14%). TET2 mutation occurred in a number of ATLL patients and was likely involved in their leukemogenesis. [J Clin Exp Hematop 55(3) : 145-149, 2015]

Journal

• Journal of Clinical and Experimental Hematopathology

  Journal of Clinical and Experimental Hematopathology 55 (3), 145-149, 2015

  The Japanese Society for Lymphoreticular Tissue Research

Keywords

• ATLL
• TET2
• polymorphism

Details

• CRID: 1390282679681813376
• NII Article ID: 130005119614
• DOI: 10.3960/jslrt.55.145
• ISSN: 18809952
• ISSN: 13464280
• PubMed: 26763362
• Web Site: https://www.jstage.jst.go.jp/article/jslrt/55/3/55_145/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016343844
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed