The First Case of Deceased Donor Liver Transplantation for a Patient with End-Stage Liver Cirrhosis Due to Human Immunodeficiency Virus and Hepatitis C Virus Coinfection in Japan

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抄録

We previously reported that progression of liver cirrhosis is quicker and survival is dismal in patients with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection, especially when acquired in childhood through contaminated blood products. Recently, we performed the first deceased donor liver transplantation (DDLT) for an HIV/HCV-coinfected hemophilic patient in Japan. A 40-year-old man was referred to our hospital for liver transplantation. Regular DDLT was performed using the piggyback technique with a full-sized liver graft. Cold ischemia time was 465 min, and the graft liver weighed 1,590 g. The antiretroviral therapy (ART) was switched from darunavir/ritonavir to raltegravir before the transplant for flexible usage of calcineurin inhibitors postoperatively; tenofovir was used as the baseline treatment. The postoperative course was uneventful, and the patient was discharged home on day 43. He started receiving anti-HCV treatment on day 110 with pegylated interferon, ribavirin, and simeprevir after the DDLT. Herein, we report the first case of DDLT in Japan. Meticulous management of ART and clotting factors could lead to the success of DDLT.

収録刊行物

  • Japanese Journal of Infectious Diseases

    Japanese Journal of Infectious Diseases 69(1), 80-82, 2016

    国立感染症研究所

各種コード

  • NII論文ID(NAID)
    130005120241
  • NII書誌ID(NCID)
    AA1132885X
  • 本文言語コード
    ENG
  • 資料種別
    journal article
  • ISSN
    1344-6304
  • NDL 記事登録ID
    027063729
  • NDL 請求記号
    Z53-C450
  • データ提供元
    NDL  IR  J-STAGE 
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