Formation of Polyglycine II Structure from Fatty Acid Derivatives Containing Mono-, Di- and Tri-Glycinate

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  • NODA Takumu
    Laboratory of Chemistry Faculty of Education, Chiba University
  • KONDO Sana
    Laboratory of Chemistry Faculty of Education, Chiba University
  • KADO Sayaka
    Center for Analytical Instrumentation, Chiba University
  • HASEGAWA Takeshi
    Laboratory of Solution and Interface Chemistry, Division of Environmental Chemistry, Institute for Chemical Research, Kyoto University
  • YAMADA Norihiro
    Laboratory of Chemistry Faculty of Education, Chiba University

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Other Title
  • グリシン，ジグリシン，トリグリシンを含む脂肪酸誘導体によるポリグリシンII構造の形成
  • グリシン,ジグリシン,トリグリシン オ フクム シボウサン ユウドウタイ ニ ヨル ポリグリシン Ⅱ コウゾウ ノ ケイセイ

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Abstract

We newly synthesized fatty acid-like amphiphiles that contain a glycine, diglycine, or triglycine residue, and investigated their hydrogen bonding modes. The FT-IR spectra of these amphiphiles showed a typical amide mode attributed to polyglycine II (PGII), which is called 31-helix in a broad sense. This mode was observed as a splitting band appearing at 1650 and 1640 cm−1. On the other hand, we have already shown the amide modes attributed to a β-sheet structure. The amide I mode of the parallel β-sheet gave a single peak at more than 1630 cm−1, whereas the antiparallel β-sheet absorbed at 1690 cm−1 (weak) and 1630 cm−1 (strong). The parallel β-sheet, antiparalle β-sheet, and PGII are possible structures for a small peptide such as tripeptide, and hence, the spectral chart of the three structures, demonstrated in this study, should be helpful to diagnose a secondary structure of small peptide-containing molecules.

Journal

  • KOBUNSHI RONBUNSHU

    KOBUNSHI RONBUNSHU 73 (1), 69-75, 2016

    The Society of Polymer Science, Japan

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