Prognostic value of cardiac sympathetic nerve imaging using long-term follow-up data—ischemic vs. non-ischemic heart failure etiology
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- Matsuo Shinro
- Department of Nuclear Medicine, Kanazawa University Hospital
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- Nakajima Kenichi
- Department of Nuclear Medicine, Kanazawa University Hospital
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- Nakata Tomoaki
- Cardiology Department, Hakodate Goryoukaku Hospital
書誌事項
- タイトル別名
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- Prognostic Value of Cardiac Sympathetic Nerve Imaging Using Long-Term Follow-up Data – Ischemic vs. Non-Ischemic Heart Failure Etiology –
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Background:Although there are several known prognostic determinants in heart failure (HF), individual risk profiles can vary, in particular between ischemic and non-ischemic HF background. This study investigated the difference in prognostic efficacy of cardiac 123I-meta-iodobenzylguanidine (MIBG) imaging between the 2 etiologies.Methods and Results:All 1,322 patients with HF were enrolled and followed up at most after 10 years. The HF patients were divided into 2 groups: an ischemic group (n=362) and non-ischemic group (n=960), and Cox proportional hazards model was used for data analysis. During 10 years of follow-up, 296 (22.4%) of 1,322 patients died; the mortality rates were 21.8% and 22.6% for the ischemic and non-ischemic groups, respectively. The ischemic group had greater prevalence of sudden death and lethal acute myocardial infarction, and the non-ischemic group had a higher rate of pump failure death. On multivariate Cox proportional hazards analysis using categorized variables, in the ischemic group, delayed heart-to-mediastinum ratio (HMR; P<0.0001), age (P=0.0002) and LVEF (P=0.03) were the independent significant predictors of lethal events. In the non-ischemic group, delayed HMR (P<0.0001), NYHA class (P<0.0001) and age (P<0.0001) were significant determinants of lethal outcome.Conclusions:Cardiac MIBG imaging has nearly identical prognostic value in both ischemic and non-ischemic HF, independent of cause of cardiac death. (Circ J 2016; 80: 435–441)
収録刊行物
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- Circulation Journal
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Circulation Journal 80 (2), 435-441, 2016
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205108560896
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- NII論文ID
- 130005120915
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- HANDLE
- 2297/44154
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- NDL書誌ID
- 027054708
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- PubMed
- 26638869
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- Web Site
- http://hdl.handle.net/2297/45907
- https://kanazawa-u.repo.nii.ac.jp/records/14299
- http://hdl.handle.net/2297/47021
- http://id.ndl.go.jp/bib/027054708
- https://ndlsearch.ndl.go.jp/books/R000000004-I027054708
- https://www.jstage.jst.go.jp/article/circj/80/2/80_CJ-15-0952/_pdf
- https://search.jamas.or.jp/link/ui/2016378264
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- 本文言語コード
- en
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