Predictors of Worsening Renal Function in Patients With Acute Decompensated Heart Failure Treated by Low-Dose Carperitide
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- Kawase Yuichi
- Department of Cardiovascular Medicine, Kurashiki Central Hospital
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- Kadota Kazushige
- Department of Cardiovascular Medicine, Kurashiki Central Hospital
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- Tada Takeshi
- Department of Cardiovascular Medicine, Kurashiki Central Hospital
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- Hata Reo
- Department of Cardiovascular Medicine, Kurashiki Central Hospital
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- Iwasaki Keiichiro
- Department of Cardiovascular Medicine, Kurashiki Central Hospital
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- Maruo Takeshi
- Department of Cardiovascular Medicine, Kurashiki Central Hospital
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- Katoh Harumi
- Department of Cardiovascular Medicine, Kurashiki Central Hospital
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- Mitsudo Kazuaki
- Department of Cardiovascular Medicine, Kurashiki Central Hospital
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Background:Predictors of worsening renal function (WRF: increase in serum creatinine ≥0.3 mg/dl from the value on admission) in patients with acute decompensated heart failure (ADHF) treated by low-dose carperitide (0.01–0.05 μg/kg/min) are unclear.Methods and Results:We retrospectively investigated predictors of WRF within the first 24 h of low-dose carperitide therapy in 205 patients (mean age, 75.6±12.1 years) hospitalized for ADHF and treated with low-dose carperitide between January 2006 and April 2014. WRF occurred in 14 patients (7%). A multivariate adjustment analysis showed that independent predictors of WRF within 24 h were hypotension (systolic blood pressure <90 mmHg) within 12 h (odds ratio, 8.7; 95% confidence interval, 2.38–35.88; P=0.0012) and serum creatinine on admission (odds ratio, 3.64; 95% confidence interval, 1.84–7.67; P=0.0003). In patients with estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2, the rate of WRF occurrence was higher in those complicated by hypotension than in those without hypotension (22.6% [7/31 patients] vs. 4.4% [5/113 patients], P=0.0041). In contrast, in patients with eGFR ≥60 ml/min/1.73 m2, hypotension did not influence the occurrence of WRF (0% [0/9 patients] vs. 3.9% [2/51 patients], P=NS).Conclusions:Hypotension within 12 h and renal dysfunction on admission are independent predictors of WRF within 24 h in patients with ADHF treated by low-dose carperitide. Hypotension may not cause WRF in patients with eGFR ≥60 ml/min/1.73 m2. (Circ J 2016; 80: 418–425)
収録刊行物
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- Circulation Journal
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Circulation Journal 80 (2), 418-425, 2016
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205108561920
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- NII論文ID
- 130005120916
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 027054669
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- PubMed
- 26667591
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可