A pathological study of the salivary glands of rabid dogs in the Philippines

DOI Web Site Web Site PubMed 7 Citations 26 References
  • BOONSRIROJ Hassadin
    Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
  • MANALO Daria Llenaresas
    Veterinary Research Department, Research Institute for Tropical Medicine, Department of Health, 9002 Research Drive, Filinvest Corporate City, Alabang, Muntinlupa City 1781, Philippines
  • KIMITSUKI Kazunori
    Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
  • SHIMATSU Taichi
    Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
  • SHIWA Nozomi
    Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
  • SHINOZAKI Harumi
    Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
  • TAKAHASHI Yurika
    Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
  • TANAKA Naoto
    Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
  • INOUE Satoshi
    Department of Veterinary Science, National Institute of Infectious Diseases, Toyama 1–23–1, Shinjuku-ku, Tokyo 162–8640, Japan
  • PARK Chun-Ho
    Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan

Bibliographic Information

Other Title
  • Pathology : A pathological study of the salivary glands of rabid dogs in the Philippines

Search this article

Abstract

Rabies is a zoonotic disease caused by the rabies virus. While the salivary glands are important as exit and propagation sites for the rabies virus, the mechanisms of rabies excretion remain unclear. Here, we investigated the histopathology of the salivary glands of rabid dogs and analyzed the mechanism of excretion into the oral cavity. Mandibular and parotid glands of 22 rabid dogs and three control dogs were used. Mild to moderate non-suppurative sialadenitis was observed in the mandibular glands of 19 of the 22 dogs, characterized by loss of acinar epithelium and infiltration by lymphoplasmacytic cells. Viral antigens were detected in the mucous acinar epithelium, ganglion neurons and myoepithelium. Acinar epithelium and lymphocytes were positive for anti-caspase-3 antibodies and TUNEL staining. In contrast, no notable findings were observed in the ductal epithelial cells and serous demilune. In the parotid gland, the acinar cells, myoepithelium and ductal epithelium all tested negative. These findings confirmed the path through which the rabies virus descends along the facial nerve after proliferation in the brain to reach the ganglion neurons of the mandibular gland, subsequently traveling to the acinar epithelium via the salivary gland myoepithelium. Furthermore, the observation that nerve endings passing through the myoepithelium were absent from the ductal system suggested that viral proliferation and cytotoxicity could not occur there, ensuring that secretions containing the virus are efficiently excreted into the oral cavity.

Journal

Citations (7)*help

See more

References(26)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top