Anti-apoptotic Effect of Grape Seed Proanthocyanidin Extract on Cisplatin-induced Apoptosis in Rat Testis

• Zhao Yanmeng

  Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University

• Zhang Hailian

  Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University

• Gao Liping

  Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University

抄録

This study was to investigate the possible anti-apoptotic effect of grape seed proanthocyanidin extract (GSPE) on cisplatin (CDDP)-induced testicular apoptosis in male rats. The control group was treated with physiological saline, the GSPE (400 mg/kg) group, GSPE (200 mg/kg) + CDDP group and GSPE (400 mg/kg) + CDDP group were received GSPE orally at corresponding dose respectively, for 15 consecutive days, starting 10 days before a single intraperitoneal dose of CDDP (7 mg/kg) in CDDP group and GSPE + CDDP groups. Administration of CDDP significantly reduced the weight of testis and epididymis, sperm concentration and caused significantly increase in the apoptosis rate of testicular cells and expression of Bax and Caspase-3, decrease in the expression of Bcl-2, along with some histopathological lesions in testicular tissue. Therefore, pre-treatment of GSPE to CDDP-injected rats tend to prevent CDDP-induced lose weight of organs, testicular apoptosis and histopathological lesions. Presented data have documented GSPE have improvement effects against testicular apoptosis caused by CDDP.

収録刊行物

• Food Science and Technology Research

  Food Science and Technology Research 21 (6), 805-811, 2015

  公益社団法人 日本食品科学工学会

キーワード

• cisplatin
• grape seed proanthocyanidins
• testis
• Apoptosis

詳細情報

• CRID: 1390001204458530560
• NII論文ID: 130005122047
• DOI: 10.3136/fstr.21.805
• ISSN: 18813984
• ISSN: 13446606
• Web Site: https://www.jstage.jst.go.jp/article/fstr/21/6/21_805/_pdf
• 本文言語コード: en
• データソース種別:
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