Blueberry (Vaccinium virgatum Aiton) leaf infusion ameliorates insulin resistance in mice fed a high-fat, high-sucrose diet
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- Yamasaki Masao
- Department of Biochemistry and Applied Biosciences, <sup>2</sup>Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki
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- Matsuyama Yusuke
- Department of Biochemistry and Applied Biosciences, <sup>2</sup>Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki
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- Hayasegawa Rintaro
- Department of Biochemistry and Applied Biosciences, <sup>2</sup>Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki
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- Hamada Kensaku
- Department of Biochemistry and Applied Biosciences, <sup>2</sup>Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki
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- Nishiyama Kazuo
- Department of Biochemistry and Applied Biosciences, <sup>2</sup>Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki
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- Kai Takanori
- Nanaha Corporation Company Limited
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- Kamenaga Kozo
- Nanaha Corporation Company Limited
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- Arakawa Teruaki
- Bizen Chemical Company Limited
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- Tari Hiroyuki
- Bizen Chemical Company Limited
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- Shimizu Yoshio
- Bizen Chemical Company Limited
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- Matsuura Yasushi
- Miyazaki Prefectural Food Research and Development Center
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- Yukizaki Chizuko
- Miyazaki Prefectural Food Research and Development Center
書誌事項
- タイトル別名
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- Blueberry (<i>Vaccinium virgatum</i> Aiton) Leaf Infusion Ameliorates Insulin Resistance in Mice Fed a High-fat, High-sucrose Diet
- Blueberry (Vaccinium virgatum Aiton) leaf extract ameliorates insulin resistance in mice fed a high-fat, high-sucrose diet
抄録
Blueberry (Vaccinium virgatum Aiton) leaf extract (BLEx) has attracted attention as a beneficial food component. Here, we examined the effect of dietary BLEx on glucose and lipid metabolism in mice fed a high-fat, high-sucrose diet (HFHSD). Growth parameter data showed that 3% BLEx slightly reduced body weight and adipose tissue weight accompanied by inhibition of HFHSD-induced enlargement of adipocytes. Liver weight was significantly reduced in the 3% BLEx group secondary to reduction of lipid accumulation in the hepatocytes. HFHSD-induced augmentation of fasting serum glucose levels was ameliorated by 3% BLEx. HFHSD-induced increase of fasting serum insulin level, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) also tended to be ameliorated. Oral glucose tolerance tests (OGTTs) revealed that 3% BLEx normalized HFHSD-induced elevation of the area under the curve for serum glucose, whereas dietary BLEx, even for the 3% dose, did not have a suppressive effect on the serum glucose change after OGTT. Taken together, these observations suggest that BLEx is a promising agent for the prevention of HFHSD-induced insulin resistance.
収録刊行物
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- Food Science and Technology Research
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Food Science and Technology Research 21 (6), 827-833, 2015
公益社団法人 日本食品科学工学会
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詳細情報 詳細情報について
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- CRID
- 1390001204458551936
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- NII論文ID
- 130005122050
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- ISSN
- 18813984
- 13446606
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可