Blueberry (<i>Vaccinium virgatum</i> Aiton) Leaf Infusion Ameliorates Insulin Resistance in Mice Fed a High-fat, High-sucrose Diet

• Yamasaki Masao

  Department of Biochemistry and Applied Biosciences, ²Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki

• Matsuyama Yusuke

  Department of Biochemistry and Applied Biosciences, ²Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki

• Hayasegawa Rintaro

  Department of Biochemistry and Applied Biosciences, ²Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki

• Hamada Kensaku

  Department of Biochemistry and Applied Biosciences, ²Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki

• Nishiyama Kazuo

  Department of Biochemistry and Applied Biosciences, ²Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki

• Kai Takanori

  Nanaha Corporation Company Limited

• Kamenaga Kozo

  Nanaha Corporation Company Limited

• Arakawa Teruaki

  Bizen Chemical Company Limited

• Tari Hiroyuki

  Bizen Chemical Company Limited

• Shimizu Yoshio

  Bizen Chemical Company Limited

• Matsuura Yasushi

  Miyazaki Prefectural Food Research and Development Center

• Yukizaki Chizuko

  Miyazaki Prefectural Food Research and Development Center

Bibliographic Information

Other Title

• Blueberry (Vaccinium virgatum Aiton) leaf infusion ameliorates insulin resistance in mice fed a high-fat, high-sucrose diet
• Blueberry (Vaccinium virgatum Aiton) leaf extract ameliorates insulin resistance in mice fed a high-fat, high-sucrose diet

Abstract

Blueberry (Vaccinium virgatum Aiton) leaf extract (BLEx) has attracted attention as a beneficial food component. Here, we examined the effect of dietary BLEx on glucose and lipid metabolism in mice fed a high-fat, high-sucrose diet (HFHSD). Growth parameter data showed that 3% BLEx slightly reduced body weight and adipose tissue weight accompanied by inhibition of HFHSD-induced enlargement of adipocytes. Liver weight was significantly reduced in the 3% BLEx group secondary to reduction of lipid accumulation in the hepatocytes. HFHSD-induced augmentation of fasting serum glucose levels was ameliorated by 3% BLEx. HFHSD-induced increase of fasting serum insulin level, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) also tended to be ameliorated. Oral glucose tolerance tests (OGTTs) revealed that 3% BLEx normalized HFHSD-induced elevation of the area under the curve for serum glucose, whereas dietary BLEx, even for the 3% dose, did not have a suppressive effect on the serum glucose change after OGTT. Taken together, these observations suggest that BLEx is a promising agent for the prevention of HFHSD-induced insulin resistance.

Journal

• Food Science and Technology Research

  Food Science and Technology Research 21 (6), 827-833, 2015

  Japanese Society for Food Science and Technology

Keywords

• high-fat
• high-sucrose diet
• insulin resistance
• blueberry leaf
• glucose

Details

• CRID: 1390001204458551936
• NII Article ID: 130005122050
• DOI: 10.3136/fstr.21.827
• ISSN: 18813984
• ISSN: 13446606
• Web Site: https://www.jstage.jst.go.jp/article/fstr/21/6/21_827/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed