ヘリコバクター・ピロリ感染者における慢性萎縮性胃炎の進展に及ぼす因子─摂取栄養素分析による検討─  [in Japanese] Role of dietary nutrient composition in the progression of chronic atrophic gastritis after <i>Helicobacter pylori</i> infection  [in Japanese]

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Author(s)

    • 瀬古 千佳子 SEKO Chikako
    • 京都府立医科大学大学院 医学研究科地域保健医療疫学 Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
    • 松井 大輔 MATSUI Daisuke
    • 京都府立医科大学大学院 医学研究科地域保健医療疫学 Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
    • 小山 晃英 KOYAMA Teruhide
    • 京都府立医科大学大学院 医学研究科地域保健医療疫学 Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
    • 渡邉 功 WATANABE Isao
    • 京都府立医科大学大学院 医学研究科地域保健医療疫学 Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
    • 尾崎 悦子 OZAKI Etsuko
    • 京都府立医科大学大学院 医学研究科地域保健医療疫学 Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
    • 栗山 長門 KURIYAMA Nagato
    • 京都府立医科大学大学院 医学研究科地域保健医療疫学 Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
    • 渡邊 能行 WATANABE Yoshiyuki
    • 京都府立医科大学大学院 医学研究科地域保健医療疫学 Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Graduate School of Medical Science

Abstract

ヘリコバクター・ピロリ(<i>H. pylori</i>)感染は胃がんの確実な発がん因子である。<i>H. pylori</i>感染から慢性萎縮性胃炎への進展過程における摂取食品との関連については多くの先行研究が行われているが, 栄養素摂取量との関連についての報告は少ない。そこで, 本研究は<i>H. pylori</i>感染者における慢性萎縮性胃炎陽性者と陰性者の栄養素摂取量の差異を検討した。対象者は京都在住の35歳から69歳までの健診参加者4,330人のうち<i>H. pylori</i>感染陽性者1,251人とした。解析対象者はこの内の栄養素摂取量算出を完了した女性296人とした。年齢, 喫煙, ビタミン剤服用, エネルギーによる補正を行い, 各栄養素摂取量を三分位に分けてロジスティック回帰分析を行った結果, カルシウムの中等量摂取, 多量摂取, 及び多価不飽和脂肪酸の中等量摂取は有意に慢性萎縮性胃炎のリスクを低めていた。これにより, これらの栄養素が慢性萎縮性胃炎進展の抑制と関連している可能性が示唆された。

<i>Helicobacter pylori</i> (<i>H. pylori</i>) infection has been reported as an established risk factor for atrophic gastritis and gastric cancer. Previous epidemiological studies have shown a relationship between chronic atrophic gastritis and food intake in <i>H. pylori</i>-infected subjects. Nevertheless, the role of dietary nutrient composition in the progression of chronic atrophic gastritis remains unclear. In this case-control study, we analyzed the compositions of various dietary nutrients and determined risk factors for the progression of chronic atrophic gastritis among <i>H. pylori</i>-infected subjects. <BR>A total of 4,330 subjects aged 35-69 years participated in a baseline survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Kyoto between June 2011 and November 2012. Among them, 1,251 subjects (435 men and 816 women) were serologically positive for <i>H. pylori</i> immunoglobulin G (IgG) antibody. From these subjects, this study enrolled 296 <i>H. pylori</i>-IgG-positive women and confirmed their nutrient intake from dietary history questionnaires. Logistic regression analysis based on tertile categories of subjects revealed that consumption of calcium (intermediate: odds ratio (OR) = 0.52, 95% CI = 0.28-0.96; high: OR = 0.52, 95% CI = 0.27-0.99; [<i>P</i> for trend = 0.02]) and polyunsaturated fatty acid (intermediate: OR = 0.41; 95% CI = 0.21-0.76; [<i>P</i> for trend = 0.05]) significantly decreased the risk of chronic atrophic gastritis after adjustment for age, smoking, alcohol consumption, taking vitamin tablets, and total energy intake. These data suggest that a specific composition of dietary nutrients may play a role in the development of chronic atrophic gastritis after <i>H. pylori</i> infection.

Journal

  • Nihon Shoukaki Gan Kenshin Gakkai zasshi

    Nihon Shoukaki Gan Kenshin Gakkai zasshi 54(1), 30-41, 2016

    The Japanese Society of Gastrointestinal Cancer Screening

Codes

  • NII Article ID (NAID)
    130005123140
  • NII NACSIS-CAT ID (NCID)
    AA12134881
  • Text Lang
    JPN
  • ISSN
    1880-7666
  • NDL Article ID
    027068412
  • NDL Call No.
    Z19-101
  • Data Source
    NDL  J-STAGE 
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