Application of regenerative medicine to audiology

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  • Yamamoto Norio
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University

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Other Title
  • 科学技術の進歩と聴覚医学
  • 「再生医療技術の聴覚医学への応用」

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Abstract

Rapid advances have occurred in the field of regenerative medicine due to progress in stem-cell and developmental biology. Even organs that were never considered as having the potential to naturally regenerate have become targets in regenerative medicine. Such organs include the inner ear and auditory nerve, causal organs of sensorineural hearing loss. In this review, a general overview of the current status of regenerative medicine is presented first. Then, the history and current status of regenerative medicine to treat hair cell loss are reviewed from the aspects of three important factors in regenerative medicine: 1) cells (including stem cells); 2) growth factors and other important factors for the development; 3) stem cells in situ and their niche. Several promising methods to regenerate hair cells have been reported, however, most are far from being sufficiently developed for clinical application. This is a different situation from that for the retina, because a clinical trial of stem cell therapy for the retinal disease has already started. One of the reasons for this difference is the lack of thorough knowledge of inner ear development. To achieve more efficient regeneration of hair cells, more progress in the developmental biology of the inner ear is required.

Journal

  • AUDIOLOGY JAPAN

    AUDIOLOGY JAPAN 58 (4), 219-226, 2015

    Japan Audiological Society

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