Post-Transplant Membranous Nephropathy Associated with Chronic Active Antibody-Mediated Rejection and Hepatitis C Infection after Deceased Donor Renal Transplantation
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- Doke Tomohito
- Department of Nephrology, Fujita Health University School of Medicine, Japan
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- Sato Waichi
- Department of Nephrology, Fujita Health University School of Medicine, Japan
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- Takahashi Kazuo
- Department of Nephrology, Fujita Health University School of Medicine, Japan
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- Hayashi Hiroki
- Department of Nephrology, Fujita Health University School of Medicine, Japan
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- Koide Sigehisa
- Department of Nephrology, Fujita Health University School of Medicine, Japan
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- Sasaki Hitomi
- Department of Urology, Fujita Health University School of Medicine, Japan
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- Kusaka Mamoru
- Department of Urology, Fujita Health University School of Medicine, Japan
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- Shiroki Ryoichi
- Department of Urology, Fujita Health University School of Medicine, Japan
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- Hoshinaga Kiyotaka
- Department of Urology, Fujita Health University School of Medicine, Japan
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- Takeda Asami
- Kidney Center, Japanese Red Cross Nagoya Daini Hospital, Japan
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- Yuzawa Yukio
- Department of Nephrology, Fujita Health University School of Medicine, Japan
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- Hasegawa Midori
- Department of Nephrology, Fujita Health University School of Medicine, Japan
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Abstract
A 53-year-old woman who had undergone deceased donor kidney transplantation twice, at 35 and 43 years of age, presented with renal impairment. She was infected with hepatitis C virus (HCV). The histology of the graft kidney revealed post-transplant membranous nephropathy (MN) with podocytic infolding and antibody-mediated rejection (AMR). IgG subclass staining showed fine granular deposits of IgG1 and IgG3, but not IgG4, in the glomerular capillary walls. Panel reactive antibody scores for human leukocyte antigen class I and class II were 92.67% and 66.68%, respectively. Thus, this case of post-transplanted MN was considered to be associated with AMR and HCV infection.<br>
Journal
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- Internal Medicine
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Internal Medicine 55 (4), 375-380, 2016
The Japanese Society of Internal Medicine
