12T061A and 12T061C, two new julichrome family compounds, as radical scavengers from <i>Streptomyces</i> sp.

• Komoda Toshikazu

  School of Food, Agricultural, and Environmental Sciences, Miyagi University

• Saeki Naoko

  School of Food, Agricultural, and Environmental Sciences, Miyagi University

• Koseki Yoshitaka

  Institute of Multidisciplinary Research for Advanced Materials, Tohoku University

• Kiyota Hiromasa

  Graduate School of Environmental and Life Science, Okayama University

Abstract

We identified two new radical scavengers, 12T061A (1, C₁₉H₂₀O₇) and 12T061C (2, C₂₀H₂₂O₇), from a culture of the Streptomyces sp. Spectroscopic analysis indicated that these compounds are new julichrome family compounds. Compounds 1 and 2 showed radical-scavenging activity with an ED₅₀ of 370 μM and 18 μM, respectively. Moreover, 1 showed tumor cell growth suppressive activity in HepG2 cells, (IC₅₀: 3.6 μM); however, no suppressive activity was shown in 2 (IC₅₀: > 100 μM).

Journal

• The Journal of General and Applied Microbiology

  The Journal of General and Applied Microbiology 62 (1), 1-6, 2016

  Applied Microbiology, Molecular and Cellular Biosciences Research Foundation

Keywords

• DPPH radical scavenger
• julichrome
• tumor cell growth suppressive activity

Details

• CRID: 1390282679123695488
• NII Article ID: 130005127281
• DOI: 10.2323/jgam.62.1
• ISSN: 13498037
• ISSN: 00221260
• PubMed: 26923124
• Web Site: https://www.jstage.jst.go.jp/article/jgam/62/1/62_1/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016327004
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed