Histopathological Characteristics of Post-inflamed Coronary Arteries in Kawasaki Disease-like Vasculitis of Rabbits

• Fujii Maiko

  Department of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine Graduate School of Medical Science Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate School of Medical Science

• Tanaka Hideo

  Department of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine Graduate School of Medical Science

• Nakamura Akihiro

  Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate School of Medical Science

• Suzuki Chinatsu

  Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate School of Medical Science

• Harada Yoshinori

  Department of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine Graduate School of Medical Science

• Takamatsu Tetsuro

  Department of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine Graduate School of Medical Science

• Hamaoka Kenji

  Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate School of Medical Science

抄録

Kawasaki disease (KD) is a systemic vasculitis in infants that develops predominantly in the coronary arteries. Despite the clinically transient nature of active inflammation in childhood albeit rare complications (e.g., coronary artery aneurysm), KD has recently been suggested to increase the incidence of ischemic heart diseases in young adulthood. However, little is known about the histopathology of the coronary artery long after development of the acute KD vasculitis. To address this, we conducted histological studies of rabbit coronary arteries in adolescent phase after induction of the KD-like vasculitis induced by horse serum administration. After a transmural infiltration of inflammatory cells in acute phase at day 7, the artery exhibited a gradual decrease in the number of inflammatory cells and thickening of the intima during the chronic phase up to day 90, where proteoglycans were distinctly accumulated in the intima with abundant involvement of α-smooth muscle actin (α-SMA)-positive cells, most of which accompanied expression of VCAM-1 and NF-κB. Distinct from classical atherosclerosis, inflammatory cells, e.g., macrophages, were barely detected during the chronic phase. These observations indicate that the KD-like coronary arteritis is followed by intimal thickening via accumulation of proteoglycans and proliferation of α-SMA-positive cells, reflecting aberrant coronary artery remodeling.

収録刊行物

• Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ

  Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ 49 (1), 29-36, 2016

  日本組織細胞化学会

キーワード

• Kawasaki disease
• coronary artery
• animal model
• proteoglycans
• vascular smooth muscle cells

詳細情報

• CRID: 1390001204863412096
• NII論文ID: 130005128331
• DOI: 10.1267/ahc.15028
• ISSN: 13475800
• ISSN: 00445991
• Web Site: https://www.jstage.jst.go.jp/article/ahc/49/1/49_15028/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016257936
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可