Investigation of Molecular Mechanism of JC virus Viroporin Activity
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- SUZUKI Tadaki
- Department of Pathology, National Institute of Infectious Diseases
Bibliographic Information
- Other Title
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- JCウイルスのチャネルタンパク質ビロポリンに関する研究
- 平成26年杉浦賞論文 JCウイルスのチャネルタンパク質ビロポリンに関する研究
- ヘイセイ 26ネン スギウラショウ ロンブン JC ウイルス ノ チャネルタンパクシツ ビロポリン ニ カンスル ケンキュウ
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Abstract
Viroporins are small and hydrophobic viral proteins that form pores on host cell membranes, and their expression can increase the permeability of cellular membranes and the production of progeny virus particles. JC virus (JCV) is the causative agent of progressive multifocal leukoenchephalopathy (PML). We demonstrate that JCV Agno, which is the small and hydrophobic protein, andincreases the plasma membrane permeability and virion release, acts as a viroporin. We also demonstrate that an interaction of Agno with a host cellular protein regulates the viroporin activity of Agno. These findings indicate a new paradigm in virus-host interactions regulating viroporin activity and viral replication.
Journal
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- Uirusu
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Uirusu 65 (1), 135-144, 2015
The Japanese Society for Virology
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Keywords
Details 詳細情報について
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- CRID
- 1390282680054989184
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- NII Article ID
- 130005128453
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- NII Book ID
- AN00018808
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- ISSN
- 18843433
- 00426857
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- NDL BIB ID
- 026616069
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- PubMed
- 26923968
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed