Cytokeratin 13, Cytokeratin 17, Ki-67 and p53 Expression in Upper Layers of Epithelial Dysplasia Surrounding Tongue Squamous Cell Carcinoma

• Matsuhira Akiko

  Department of Oral Medicine, Oral and Maxillofacial Surgery, Tokyo Dental College

• Noguchi Sunaki

  Department of Oral Medicine, Oral and Maxillofacial Surgery, Tokyo Dental College

• Sato Kazumichi

  Oral Cancer Center, Tokyo Dental College

• Tanaka Yoichi

  Division of Surgical Pathology, Clinical Laboratory, Ichikawa General Hospital, Tokyo Dental College

• Yamamoto Gou

  Department of Oral Pathology and Diagnosis, School of Dentistry, Showa University

• Mishima Kenji

  Department of Oral Pathology and Diagnosis, School of Dentistry, Showa University

• Katakura Akira

  Department of Oral Medicine, Oral and Maxillofacial Surgery, Tokyo Dental College

抄録

Early detection of oral squamous cell carcinoma (OSCC) improves its prognosis and aids in selecting the appropriate treatment, which may also have a positive effect on quality of life. Early detection, therefore, is an important issue in the treatment of this disease. The purpose of this study was to investigate expression of cytokeratin 13 (CK13), CK17, Ki-67 and p53 as potential markers of tongue SCC. Five areas in 12 specimens were examined: the upper and lower layers of normal epithelium; those of dysplastic epithelial tissue surrounding the cancerous lesion; and the lesion itself. Strong expression of each of the following mRNAs and proteins was observed; CK13 in upper layers of normal epithelium; Ki-67 and p53 in lower layers of normal epithelium; CK13 and CK17 in upper layer of epithelial dysplasia; and CK17, Ki-67, and p53 in lower layer of epithelial dysplasia and cancerous lesions. These results indicate that the characteristic pattern of expression of CK13 and CK17 differs between normal and dysplastic oral epithelium. Oral epithelial dysplasia adjacent to OSCC has high malignant potential, and is similar to early-stage OSCC. This suggests that evaluation of these markers could be a useful secondary procedure for improving detection of early-stage OSCC.

収録刊行物

• The Bulletin of Tokyo Dental College

  The Bulletin of Tokyo Dental College 56 (4), 223-231, 2015

  東京歯科大学

キーワード

• Oral squamous cell carcinoma
• Oral epithelial dysplasia
• Cytokeratin 17
• Cytokeratin 13
• Laser capture microdissection

詳細情報

• CRID: 1390001204588743808
• NII論文ID: 130005129281
• NII書誌ID: AA00592969
• DOI: 10.2209/tdcpublication.56.223
• ISSN: 00408891
• PubMed: 26657521
• Web Site: https://www.jstage.jst.go.jp/article/tdcpublication/56/4/56_223/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016292809
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可