Clinical role of Foxp3⁺regulatory T cell in Living donor related liver transplantation for prediction of life-threatening complications

• Asanoma Michihito

  The Department of Surgery, the University of Tokushima

• Mori Hiroki

  The Department of Surgery, the University of Tokushima

• Ikemoto Tetsuya

  The Department of Surgery, the University of Tokushima

• Utsunomiya Toru

  The Department of Surgery, the University of Tokushima

• Imura Satoru

  The Department of Surgery, the University of Tokushima

• Morine Yuji

  The Department of Surgery, the University of Tokushima

• Hanaoka Jun

  The Department of Surgery, the University of Tokushima

• Kanamoto Mami

  The Department of Surgery, the University of Tokushima

• Saito Yu

  The Department of Surgery, the University of Tokushima

• Yamada Shinichiro

  The Department of Surgery, the University of Tokushima

• Shimada Mitsuo

  The Department of Surgery, the University of Tokushima

Bibliographic Information

Other Title

• Clinical role of Foxp3+regulatory T cell in Living donor related liver transplantation for prediction of life-threatening complications

Abstract

Purposes: It is no doubt that regulatory T cells (Foxp3⁺CD4⁺CD25⁺T cells: Treg) play important roles in transplant immunity. We investigated the significance of Treg expression in acute stage of living donorrelated liver transplantation (LDLT) for the possibility of the sensitive marker for immunological state and homeostatic stress after liver transplantation. Methods: Peripheral blood was drawn from 5 recipients of LDLT preoperatively and on post operative 1, 4, 7, and 14 days. The peripheral blood mononuclear cells (PBMCs) were stained with CD4, CD25, Foxp3, and were analyzed with FACScan. This data was compared with clinical output of LDLT. Result: The populations of Treg were significantly decreased in all patients on day 1 after LDLT and significantly increased in patients who had early postoperative complications compared with patients who had no complications. Conclusions: The population of Treg in peripheral blood may reflect the surgical stress such as life-threatening complications after LDLT. J. Med. Invest. 62: 37-40, February, 2015

Journal

• The Journal of Medical Investigation

  The Journal of Medical Investigation 62 (1.2), 37-40, 2015

  The University of Tokushima Faculty of Medicine

Keywords

• Liver transplantation
• regulatory T cells
• Foxp3
• Transplant immunology

Details

• CRID: 1390001204244963712
• NII Article ID: 130005129689
• NII Book ID: AA11166929
• DOI: 10.2152/jmi.62.37
• ISSN: 13496867
• ISSN: 13431420
• PubMed: 25817281
• Web Site: https://repo.lib.tokushima-u.ac.jp/111243
• Web Site: https://www.jstage.jst.go.jp/article/jmi/62/1.2/62_37/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016077518
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed