Tube Radial Distribution Chromatography on a Microchip Incorporating Microchannels with a Three-to-One Channel Confluence Point

• SUZUKI Naomichi

  Department of Chemical Engineering and Materials Science, Doshisha University

• YAMASHITA Kenichi

  Advanced Manufacturing Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)

• MAEDA Hideaki

  Advanced Manufacturing Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)

• HASHIMOTO Masahiko

  Department of Chemical Engineering and Materials Science, Doshisha University

• TSUKAGOSHI Kazuhiko

  Department of Chemical Engineering and Materials Science, Doshisha University Tube Radial Distribution Phenomenon Research Center, Doshisha University

Abstract

We developed a capillary chromatography system using a phase-separated solvent mixture as a carrier solution—i.e., a water-hydrophilic/hydrophobic organic solvent mixture—which we call “tube radial distribution chromatography” (TRDC). Here, we attempted to apply the TRDC system to a microchip incorporating microchannels with a double T-junction for injection of analyte solution and a three-to-one, narrow-to-wide channel confluence point for tube radial distribution phenomenon (TRDP) at room temperature. A ternary mixed solvent of water, acetonitrile and ethyl acetate was used as a carrier solution. TRDP in the wide microchannel was examined using various flow rates, temperatures, and component solvent ratios. Successful observation was carried out using a fluorescence microscope-CCD camera. Model analytes perylene (hydrophobic) and Eosin Y (hydrophilic) were separated by flowing through the microchannel, without any treatment such as packed columns or coating, at room temperature (25°C).

Journal

• Analytical Sciences

  Analytical Sciences 31 (12), 1267-1272, 2015

  The Japan Society for Analytical Chemistry

Keywords

• Tube radial distribution phenomenon (TRDP)
• tube radial distribution chromatography (TRDC)
• tube radial distribution mixing (TRDM)
• microchannel

Details

• CRID: 1390001204261542144
• NII Article ID: 130005129727
• NII Book ID: AA10500785
• DOI: 10.2116/analsci.31.1267
• ISSN: 13482246
• ISSN: 09106340
• NDL BIB ID: 027106726
• PubMed: 26656816
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027106726
• Web Site: https://link.springer.com/content/pdf/10.2116/analsci.31.1267.pdf
• Web Site: https://link.springer.com/article/10.2116/analsci.31.1267/fulltext.html
• Web Site: https://www.jstage.jst.go.jp/article/analsci/31/12/31_1267/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed