Heterogeneous Effects of Association Between Blood Pressure Loci and Coronary Artery Disease in East Asian Individuals
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- Takeuchi Fumihiko
- Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine
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- Isono Masato
- Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine
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- Yamamoto Ken
- Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University
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- Yokota Mitsuhiro
- Department of Genome Science, Aichi-Gakuin University, School of Dentistry
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- Akiyama Koichi
- Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine
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- Katsuya Tomohiro
- Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine
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- Kim Hyo-Soo
- Department of Internal Medicine, Cardiovascular Center, Seoul National University Hospital
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- Park Jeong Euy
- Division of Cardiology, Samsung Medical Center
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- Jang Yangsoo
- Cardiology Division, Department of Internal Medicine, Cardiovascular Genome Center, Yonsei University College of Medicine,
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- Lee Ji-Young
- Center for Genome Science, Korea National Institute of Health, KCDC
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- Lee Jong-Young
- Center for Genome Science, Korea National Institute of Health, KCDC
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- Kato Norihiro
- Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine
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Background:A coronary artery disease (CAD) association study of genetic loci previously identified as being associated with blood pressure (BP) was performed in east Asian populations.Methods and Results:Nine single nucleotide polymorphisms (SNPs) from 9 candidate loci robustly confirmed to be associated with BP in east Asian people, were genotyped. Genotyping was done in up to 17,785 CAD case-control samples (6,522 cases and 11,263 controls). We then tested the associations with other metabolic traits (n≤17,900) and with type 2 diabetes (931 cases and 1,404 controls), and looked up the datasets in silico in other populations. Significant (adjusted P<0.05) CAD associations were found for 5 BP loci: 3 new CAD associations atFIGN,FGF5andNPR3, and 2 previously reported ones atATP2B1andCNNM2. The strongest CAD association was detected atATP2B1rs2681472 (P=1.7×10–8), in the direction inverted to what is generally recognized for BP in the epidemiological studies.CNNM2rs12413409 showed significant association with CAD (P=8.7×10–7) and BMI (P=3.5×10–8, when meta-analyzed with 75,807 east Asian people). The genetic risk score combining BP-raising alleles at each of the SNPs was positively associated with CAD (P=0.011).Conclusions:A substantial proportion of genetic variants associated with BP were also associated with the risk of CAD in east Asian people, and there was some counter-evidence for causal inference. (Circ J 2015; 79: 830–838)
収録刊行物
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- Circulation Journal
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Circulation Journal 79 (4), 830-838, 2015
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205107468800
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- NII論文ID
- 40020412372
- 130005130251
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 026283908
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- PubMed
- 25740055
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- 本文言語コード
- en
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- データソース種別
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- PubMed
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