Impact of Peripheral Artery Disease on Prognosis in Hospitalized Heart Failure Patients

• Nakamura Yuichi

  Department of Cardiology and Hematology, Fukushima Medical University

• Kunii Hiroyuki

  Department of Cardiology and Hematology, Fukushima Medical University

• Yoshihisa Akiomi

  Department of Cardiology and Hematology, Fukushima Medical University Department of Advanced Cardiac Therapeutics, Fukushima Medical University

• Takiguchi Mai

  Department of Cardiology and Hematology, Fukushima Medical University

• Shimizu Takeshi

  Department of Cardiology and Hematology, Fukushima Medical University

• Yamauchi Hiroyuki

  Department of Cardiology and Hematology, Fukushima Medical University

• Iwaya Shoji

  Department of Cardiology and Hematology, Fukushima Medical University

• Owada Takashi

  Department of Cardiology and Hematology, Fukushima Medical University

• Abe Satoshi

  Department of Cardiology and Hematology, Fukushima Medical University

• Sato Takamasa

  Department of Cardiology and Hematology, Fukushima Medical University

• Suzuki Satoshi

  Department of Cardiology and Hematology, Fukushima Medical University Department of Advanced Cardiac Therapeutics, Fukushima Medical University

• Oikawa Masayoshi

  Department of Cardiology and Hematology, Fukushima Medical University

• Kobayashi Atsushi

  Department of Cardiology and Hematology, Fukushima Medical University

• Yamaki Takayoshi

  Department of Cardiology and Hematology, Fukushima Medical University

• Sugimoto Koichi

  Department of Cardiology and Hematology, Fukushima Medical University

• Nakazato Kazuhiko

  Department of Cardiology and Hematology, Fukushima Medical University

• Suzuki Hitoshi

  Department of Cardiology and Hematology, Fukushima Medical University

• Saitoh Shu-ichi

  Department of Cardiology and Hematology, Fukushima Medical University

• Takeishi Yasuchika

  Department of Cardiology and Hematology, Fukushima Medical University Department of Advanced Cardiac Therapeutics, Fukushima Medical University

抄録

Background:The impact of peripheral artery disease (PAD) on heart failure (HF) prognosis remains unclear.Methods and Results:A total of 388 consecutive decompensated HF patients were divided into 2 groups based on the presence of PAD: HF with PAD (PAD group, n=101, 26.0%) and HF without PAD (non-PAD group, n=287, 74.0%). We compared clinical features, echocardiographic parameters, cardiopulmonary exercise testing results, laboratory findings, as well as cardiac, non-cardiac, and all-cause mortality between the 2 groups. The PAD group, as compared with the non-PAD group, had (1) higher prevalence of coronary artery disease (40.6 vs. 27.5%, P=0.011) and cerebrovascular disease (34.7 vs. 18.2%, P=0.001); (2) higher tumor necrosis factor-α (1.82 vs. 1.49 pg/ml, P=0.023), C-reactive protein (0.32 vs. 0.19 mg/dl, P=0.045), and troponin T (0.039 vs. 0.021 ng/ml, P=0.019); (3) lower LVEF (42.4 vs. 48.5%, P<0.001); (4) lower peak V̇O₂(13.4 vs. 15.9 ml·kg^–1·min^–1, P=0.001); and (5) higher V̇E/V̇CO₂slope (38.8 vs. 33.7, P<0.001). On Kaplan-Meier analysis, cardiac, non-cardiac, and all-cause mortality were significantly higher in the PAD group than in the non-PAD group (P<0.05, respectively). On Cox proportional hazard analysis after adjusting for confounding factors, PAD was an independent predictor of cardiac and all-cause mortality (P<0.05, respectively) in HF patients.Conclusions:PAD was common and an independent predictor of cardiac and all-cause mortality in HF patients. (Circ J 2015; 79: 785–793)

収録刊行物

• Circulation Journal

  Circulation Journal 79 (4), 785-793, 2015

  一般社団法人 日本循環器学会

キーワード

• Cardiovascular event
• Exercise
• Heart failure
• Mortality
• Peripheral artery disease

詳細情報

• CRID: 1390001205107476608
• NII論文ID: 40020412282
• NII論文ID: 130005130257
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-14-1280
• ISSN: 13474820
• ISSN: 13469843
• NDL書誌ID: 026283780
• PubMed: 25739573
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026283780
• Web Site: https://www.jstage.jst.go.jp/article/circj/79/4/79_CJ-14-1280/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015311435
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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