<b>Jagged1 Stimulates Bone Resorption during Orthodontic Tooth Movement </b>

• Odaira-Yamazaki Mami

  Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan

• Yamaguchi Masaru

  Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan

• Kikuta Jun

  Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan

• Shimizu Mami

  Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan

• Yoshino Tomokazu

  Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan

• Hikida Takuji

  Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan

• Takahashi Momoko

  Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan

• Kasai Kazutaka

  Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan

抄録

In this study, we first investigated the expression of Jagged1 at compression sites during experimental tooth movement in rats in vivo. We then assessed the effects of compression force on Jagged1 production from human periodontal ligament (hPDL) cells.<br>　Twelve 6-week old male Wistar rats were subjected to an orthodontic force of 10 g in order to induce mesial tipping movement of the upper first molars for 7 days. Expression levels of tartrate-resistant acid phosphatase and Jagged1 proteins in the alveolar bone were determined by immunohistochemical analysis. Furthermore, the effects of compression force on Jagged1 production were investigated using hPDL cells in vitro.<br>　Under conditions of experimental tooth movement in vivo, resorption lacunae with multinucleated cells were observed in the 10 g group. In addition, immunoreactivity for Jagged1 was detected on day 7 in PDL tissue subjected to orthodontic force. In the in vitro study, compression force increased the production of Jagged1 from the hPDL cells in a time-dependent manner.<br>　These results suggest that Jagged1 stimulates alveolar bone resorption during orthodontic tooth movement.

収録刊行物

• ＩＪＯＭＳ

  ＩＪＯＭＳ 13 (2), 59-65, 2015

  日本大学松戸歯学部 口腔科学研究所

キーワード

• Jagged1, tooth movement, compression force, periodontal ligament

詳細情報

• CRID: 1390001205213485056
• NII論文ID: 130005130354
• DOI: 10.5466/ijoms.13.59
• ISSN: 21854254
• ISSN: 13479733
• Web Site: https://www.jstage.jst.go.jp/article/ijoms/13/2/13_59/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015328717
• 本文言語コード: en
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