CDH13 polymorphisms are associated with adiponectin levels and metabolic syndrome traits independently of visceral fat mass
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- Kitamoto Aya
- Pharmacogenomics, Kyoto University Graduate School of Medicine
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- Kitamoto Takuya
- Pharmacogenomics, Kyoto University Graduate School of Medicine
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- Nakamura Takahiro
- Laboratory for Mathematics, National Defense Medical College
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- Matsuo Tomoaki
- Graduate School of Comprehensive Human Sciences, University of Tsukuba
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- Nakata Yoshio
- Graduate School of Comprehensive Human Sciences, University of Tsukuba
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- Hyogo Hideyuki
- Department of Gastroenterology and Hepatology, JA Hiroshima General Hospital
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- Ochi Hidenori
- Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences, Hiroshima University
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- Kamohara Seika
- Health Science University
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- Miyatake Nobuyuki
- Department of Hygiene, Faculty of Medicine, Kagawa University
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- Kotani Kazuaki
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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- Mineo Ikuo
- Otemae Hospital
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- Wada Jun
- Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- Ogawa Yuji
- Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine
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- Yoneda Masato
- Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine
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- Nakajima Atsushi
- Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine
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- Funahashi Tohru
- Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University
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- Miyazaki Shigeru
- Tokyo Postal Services Agency Hospital
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- Tokunaga Katsuto
- Itami City Hospital
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- Masuzaki Hiroaki
- Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Graduate School of Medicine, University of the Ryukyus
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- Ueno Takato
- Research Center for Innovative Cancer Therapy, Kurume University
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- Chayama Kazuaki
- Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences, Hiroshima University
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- Hamaguchi Kazuyuki
- Department of Practical Nursing Science, Faculty of Medicine, Oita University
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- Yamada Kentaro
- Division of Endocrinology and Metabolism, Department of Medicine, Kurume University
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- Hanafusa Toshiaki
- Department of Internal Medicine (I), Osaka Medical College
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- Oikawa Shinichi
- Diabetes and Lifestyle Disease Center, Fukujuji Hospital
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- Sakata Toshiie
- Department of Internal Medicine 1, Faculty of Medicine, Oita University
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- Tanaka Kiyoji
- Graduate School of Comprehensive Human Sciences, University of Tsukuba
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- Matsuzawa Yuji
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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- Hotta Kikuko
- Department of Medical Innovation, Osaka University Hospital
書誌事項
- タイトル別名
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- <i>CDH13</i> Polymorphisms are Associated with Adiponectin Levels and Metabolic Syndrome Traits Independently of Visceral Fat Mass
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抄録
Aim: Visceral fat accumulation contributes to the development of metabolic syndrome. As visceral fat accumulation increases, adiponectin levels decrease; therefore, adiponectin provides a link between visceral fat accumulation and metabolic disorders. Genome-wide association studies (GWASs) have identified genetic variations in the cadherin 13 (CDH13) gene that are associated with adiponectin levels.<br>Methods: We investigated whether single nucleotide polymorphisms (SNPs) in CDH13 was associated with adiponectin levels and metabolic syndrome traits independent of the visceral fat area (VFA), as measured using computed tomography (CT) in 945 Japanese individuals.<br>Results: We found that three CDH13 SNPs reported by recent GWASs (i.e., rs3865188, rs4783244, and rs12051272) were significantly associated with higher adiponectin levels (P＜1×10 －14 ), even after adjustment for VFA. However, these adiponectin-inducing alleles of CDH13 SNPs were significantly associated with traits consistent with deteriorating metabolic symptoms, such as higher fasting insulin, homeostasis model assessment–insulin resistance (HOMA-IR) scores, and triglycerides and lower high-density lipoprotein (HDL)-cholesterol levels, similar to increasing VFA and decreasing adiponectin levels.<br>Conclusion: These results suggested that CDH13 SNPs cause an adiponectin-resistant status to compensate for increasing adiponectin levels and could result in the deterioration of metabolic syndrome traits.
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ
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Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ 23 (3), 309-319, 2016
一般社団法人 日本動脈硬化学会