Combined effects of soy isoflavones and milk basic protein on bone mineral density in hind-limb unloaded mice

• Matsumoto Yu

  Department of Food Function and Labeling, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition

• Tousen Yuko

  Department of Food Function and Labeling, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition

• Nishide Yoriko

  Department of Food Function and Labeling, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition

• Tadaishi Miki

  Department of Nutritional Science, Tokyo University of Agriculture

• Kato Ken

  Milk Science Research Institute, Megmilk Snow Brand Co., Ltd.

• Ishimi Yoshiko

  Department of Food Function and Labeling, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition

抄録

We examined whether the combination of isoflavone and milk basic protein both are reported to be effective for bone metabolism, prevents bone loss induced by skeletal hind-limb unloading in mice. Female ddY strain mice, aged 8 weeks, were divided into six groups (n = 6–8 each): (1) normally housed group, (2) loading group, (3) hind-limb unloading group fed a control diet, (4) hind-limb unloading group fed a 0.2% isoflavone conjugates diet, (5) hind-limb unloading group fed a 1.0% milk basic protein diet, and (6) hind-limb unloading group fed a 0.2% isoflavone conjugates and 1.0% milk basic protein diet. After 3 weeks, femoral bone mineral density was markedly reduced in unloading mice. The combination of isoflavone and milk basic protein showed cooperative effects in preventing bone loss and milk basic protein inhibited the increased expression of osteogenic genes in bone marrow cells in unloading mice. These results suggest that the combination of soy isoflavone and milk basic protein may be useful for bone health in subjects with disabling conditions as well as astronauts.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ 58 (2), 141-145, 2016

  一般社団法人　日本酸化ストレス学会

キーワード

• hindlimb-unloading
• bone mineral density
• soy isoflavones
• milk basic protein (MBP)

詳細情報

• CRID: 1390282679648715520
• NII論文ID: 130005132518
• DOI: 10.3164/jcbn.14-137
• ISSN: 18805086
• ISSN: 09120009
• Web Site: https://www.jstage.jst.go.jp/article/jcbn/58/2/58_14-137/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016329674
• 本文言語コード: en
• データソース種別:
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