Metallomics approach to changes in element concentration during differentiation from fibroblasts into adipocytes by element array analysis

• Ogra Yasumitsu

  Department of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University Laboratory of Chemical Toxicology and Environmental Health, Showa Pharmaceutical University

• Nagasaki Shu

  Laboratory of Chemical Toxicology and Environmental Health, Showa Pharmaceutical University

• Yawata Ayako

  Laboratory of Chemical Toxicology and Environmental Health, Showa Pharmaceutical University

• Anan Yasumi

  Laboratory of Chemical Toxicology and Environmental Health, Showa Pharmaceutical University

• Hamada Koichi

  Department of Pharmacotherapeutics, Showa Pharmaceutical University

• Mizutani Akihiro

  Department of Pharmacotherapeutics, Showa Pharmaceutical University

抄録

We aimed to establish an element array analysis that involves the simultaneous detection of all elements in cells and the display of changes in element concentration before and after a cellular event. In this study, we demonstrated changes in element concentration during the differentiation of 3T3-L1 mouse fibroblasts into adipocytes. This metallomics approach yielded unique information of cellular response to physiological and toxicological events.

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 41 (2), 241-244, 2016

  一般社団法人　日本毒性学会

キーワード

• Metallomics
• Differentiation
• Fibroblast
• Adipocyte
• 3T3-L1

詳細情報

• CRID: 1390001204905916416
• NII論文ID: 130005132657
• NII書誌ID: AN00002808
• DOI: 10.2131/jts.41.241
• ISSN: 18803989
• ISSN: 03881350
• NDL書誌ID: 027267888
• PubMed: 26961608
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027267888
• Web Site: https://www.jstage.jst.go.jp/article/jts/41/2/41_241/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016296489
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可