Acute oral toxicity test of chemical compounds in silkworms
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- Usui Kimihito
- Genome Pharmaceuticals Institute Co., Ltd.
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- Nishida Satoshi
- Genome Pharmaceuticals Institute Co., Ltd. Department of Microbiology and Immunology, Teikyo University School of Medicine
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- Sugita Takuya
- Noevir Co., Ltd. Tokyo Research Laboratory
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- Ueki Takuro
- Noevir Co., Ltd. Tokyo Research Laboratory
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- Matsumoto Yasuhiko
- Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- Okumura Hidenobu
- Noevir Co., Ltd. Tokyo Research Laboratory
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- Sekimizu Kazuhisa
- Genome Pharmaceuticals Institute Co., Ltd. Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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抄録
This study performed an acute oral toxicity test of 59 compounds in silkworms. These compounds are listed in OECD guidelines as standard substances for a cytotoxicity test, and median lethal dose (LD50) werecalculated for each compound. Acute oral LD50 values in mammals are listed in OECD guidelines and acute oral LD50 values in silkworms were determined in this study. R2 for the correlation between LD50 values in mammals and LD50 values in silkworms was 0.66. In addition, the acute oral toxicity test in silkworms was performed by two different facilities, and test results from the facilities were highly reproducible. These findings suggest that an acute oral toxicity test in silkworms is a useful way to evaluate the toxicity of compounds in mammals.
収録刊行物
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- Drug Discoveries & Therapeutics
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Drug Discoveries & Therapeutics 10 (1), 57-61, 2016
特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会