Identification of lysocin E using a silkworm model of bacterial infection
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- Hamamoto Hiroshi
- Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- Sekimizu Kazuhisa
- Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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抄録
New antimicrobials with novel mechanisms need to be developed to combat antimicrobial-resistant pathogenic bacteria. The current authors recently reported discovery of a new antibiotic named "Lysocin E". Lysocin E was identified using a silkworm model of bacterial infection. The current review discusses the advantages of using a silkworm model of bacterial infection to identify and develop therapeutically efficacious antimicrobials. This review also discusses the discovery of lysocin E and its novel mechanism of action.
収録刊行物
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- Drug Discoveries & Therapeutics
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Drug Discoveries & Therapeutics 10 (1), 24-29, 2016
特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会