A hyperglycemic silkworm model for evaluating hypoglycemic activity of Rehmanniae Radix, an herbal medicine
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- Matsumoto Yasuhiko
- Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- Sekimizu Kazuhisa
- Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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抄録
Silkworm shows hyperglycemia after intake of diet containing large amount of glucose. The hyperglycemic silkworm model is useful for evaluation of anti-diabetic drugs. A hot water extract of Rehmanniae Radix, an herbal medicine, showed hypoglycemic effect against the hyperglycemic silkworms. This method is applicable for quick and simple evaluation of the hypoglycemic activities of different batches of Rehmanniae Radix. Our findings suggest that silkworms have a lot of merit as experimental animals for evaluation of various herbal medicines.
収録刊行物
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- Drug Discoveries & Therapeutics
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Drug Discoveries & Therapeutics 10 (1), 14-18, 2016
特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会