唾液腺機能障害に対する再生へのアプローチ

DOI
  • 阪井 丘芳
    大阪大学大学院歯学研究科高次脳口腔機能学講座顎口腔機能治療学教室

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  • Regenerative approach for the dysfunction of salivary gland

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Radiation therapy and Sjogren's syndrome cause salivary gland hypofunction, known as xerostomia. Xerostomia remarkably reduces quality of life. This report reviews current studies in basic science and translational research toward treatments for patients suffering from dysfunction and hypofunction of the salivary gland. Here we describe recent researches that have enabled us to understand the mechanisms of salivary gland development and regeneration. In addition, we introduce new approaches to recovering salivary gland function utilizing both gene and cell-based therapy. A good understanding of the mechanisms of salivary gland development facilitates the design of excellent treatments for regeneration and repair of damaged salivary glands.

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