Cancerous‐region enhancement utilizing gadolinium‐oxide nanoparticles and 7.0‐T magnetic resonance imaging

• SATO Eiichi

  Department of Physics, Iwate Medical University

• HAGIWARA Osahiko

  Department of Surgery, Toho University Ohashi Medical Center

• MATSUKIYO Hiroshi

  Department of Surgery, Toho University Ohashi Medical Center

• WATANABE Manabu

  Department of Surgery, Toho University Ohashi Medical Center

• KUSACHI Shinya

  Department of Surgery, Toho University Ohashi Medical Center

• METOKI Tsuyoshi

  Central Radiation Department, Iwate Medical University Hospital

• SATO Yuichi

  Central Radiation Department, Iwate Medical University Hospital

• ODA Yasuyuki

  Department of Physics, Iwate Medical University

• SAGAE Michiaki

  Department of Physics, Iwate Medical University

• YAMAGUCHI Satoshi

  Department of Radiology, School of Medicine, Iwate Medical University

• EHARA Shigeru

  Department of Radiology, School of Medicine, Iwate Medical University

Abstract

Cancerous‐region enhancement using gadolinium‐oxide（Gd₂O₃）suspension and 7.0‐T magnetic resonance imaging is described. The suspension consists of the saline and the Gd₂O₃ nanoparticles with an average diameter of less than 15nm. Six glass vials are filled with six‐different Gd densities of 0, 10, 20, 50, 100 and 200μg/ml. Utilizing T1‐weighted imaging（T1WI）, the signal intensity（image density）of Gd media seldom varied with changes in the Gd density. However, the signal intensity decreased with increasing Gd density utilizing T2*‐weighted imaging（T2*WI）. The minimum‐detectable Gd density was approximately 20μg/ml, and the minimum‐detectable Gd molar density of approximately 120 n mol/ml was higher than that of Fe in ferucarbotran colloid for liver‐cancer imaging. Subsequently, the signal intensity of the VX2‐cancer region around the cancerous milk in a rabbit thigh decreased by the femoral‐vein injection of the Gd₂O₃ suspension utilizing T2*WI. The VX2 is a popular rabbit cancer sold at laboratory‐animal breeding companies. After seven days from the injection, we observed the Gd₂O₃ nanoparticles remained in the cancerous region.

Journal

• Medical Imaging and Information Sciences

  Medical Imaging and Information Sciences 33 (1), i-vi, 2016

  MEDICAL IMAGING AND INFORMATION SCIENCES

Keywords

• cancerous‐region enhancement
• Gd₂O₃ nanoparticle
• nanoparticle suspension
• negative contrast medium
• 7T‐MRI

Details

• CRID: 1390001204653107456
• NII Article ID: 130005139436
• DOI: 10.11318/mii.33.i
• ISSN: 18804977
• ISSN: 09101543
• Text Lang: en
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed