Hashimoto’s encephalopathy presenting with vertigo and muscle weakness in a male pediatric patient

• Ueno Hiroe

  Department of Pediatrics, National Hospital Organization, Kumamoto Saisyunsou National Hospital

• Nishizato Chizuru

  Department of Pediatrics, National Hospital Organization, Kumamoto Saisyunsou National Hospital

• Shimazu Tomoyuki

  Department of Pediatrics, National Hospital Organization, Kumamoto Saisyunsou National Hospital

• Watanabe Hiziri

  Department of Pediatrics, Minamata City General Hospital and Medical Center

• Mizukami Tomoyuki

  Department of Pediatrics, National Hospital Organization, Kumamoto Medical Center

• Kosuge Hiroshi

  Department of Pediatrics, Kumamoto University Hospital

• Ozasa Shiro

  Department of Pediatrics, Kumamoto University Hospital

• Nomura Keiko

  Department of Pediatrics, Kumamoto University Hospital

• Kimura Shigemi

  Department of Pediatrics, Kumamoto University Hospital

• Takahashi Yukitoshi

  Department of Pediatrics, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders

Bibliographic Information

Other Title

• めまいで発症し亜急性に四肢の筋力低下・歩行障害が進行した橋本脳症の1男児例

Abstract

  Hashimoto’s encephalopathy is an anti-thyroid antibody-positive autoimmune encephalopathy. We herein report the case of a 13-year-old male patient with subacute vertigo, muscle weakness in the extremities and gait disturbance who was diagnosed with Hashimoto’s encephalopathy. He showed no severe impairment of consciousness and no seizures, and there were no abnormalities on the brain MRI. However, epileptic spike and wave complexes were observed on an electroencephalogram, and a decline in blood flow was diffusely observed on brain SPECT (single photon emission computed tomography). His thyroid function was normal, but he was positive for anti-thyroid antibodies, such as anti-TPO (thyroid peroxidase) antibodies. He was also positive for serum anti-NAE (NH2-terminal alpha-enolase) antibodies. Systemic corticosteroid therapy and high-dose intravenous immunoglobulin therapy were effective, greatly improving his quality of life.

Journal

• NO TO HATTATSU

  NO TO HATTATSU 48 (1), 45-47, 2016

  The Japanese Society of Child Neurology

Keywords

• 橋本脳症
• 抗甲状腺抗体
• 抗NAE抗体
• 免疫グロブリン大量療法
• ステロイドパルス療法

Details

• CRID: 1390282680494587904
• NII Article ID: 130005140033
• DOI: 10.11251/ojjscn.48.45
• ISSN: 18847668
• ISSN: 00290831
• Web Site: https://search.jamas.or.jp/link/ui/2016220168
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed