Successful treatment with chloramphenicol in four pediatric cases of intractable bacterial meningitis

• Morita Kayo

  Department of Pediatrics, Saitama Medical University School of Medicine

• Abe Yu-ichi

  Department of Pediatrics, Saitama Medical University School of Medicine

• Itano Atsushi

  Department of Pediatrics, Saitama Medical University School of Medicine

• Musha Ikuma

  Department of Pediatrics, Saitama Medical University School of Medicine

• Koga Takeshi

  Department of Pediatrics, Saitama Medical University School of Medicine

• Yamazaki Taro

  Department of Pediatrics, Saitama Medical University School of Medicine

• Yamanouchi Hideo

  Department of Pediatrics, Saitama Medical University School of Medicine

Bibliographic Information

Other Title

• Chloramphenicolが著効した小児難治性細菌性髄膜炎の4例

Abstract

  Chloramphenicol (CP) is recently one of the rarely-used antibiotics. In this study, we present four patients with intractable bacterial meningitis, who were successfully treated with CP and discuss the therapeutic indications of CP in these pediatric cases. The patients were diagnosed as bacterial meningitis at the ages ranging from 2 months to 1 year and 4 months. The causative organisms found in three of the patients were H. influenzae and in the fourth patient, S. pneumoniae. According to the microbial sensitivity tests, these organisms were highly sensitive to antibiotics including ceftriaxone, meropenem and/or panipenem/betamipron. Treatment with these antibiotics was initially effective; however, recurrences of meningitis appeared in all patients. Administration of CP (100 mg/kg/day) started between the 11th and the 58th days, and was continued for 9 days up to 19 days. Their fever had disappeared within four days after the administration of CP, and it was confirmed that all patients completely recovered from meningitis. Two of the patients developed a mild degree of anemia, but soon recovered after the discontinuation of CP. None of them had neurological sequela. We recommend CP as one of the choices for the treatment of intractable bacterial meningitis.

Journal

• NO TO HATTATSU

  NO TO HATTATSU 48 (1), 29-33, 2016

  The Japanese Society of Child Neurology

Keywords

• chloramphenicol

Details

• CRID: 1390282680494590464
• NII Article ID: 130005140037
• DOI: 10.11251/ojjscn.48.29
• ISSN: 18847668
• ISSN: 00290831
• Web Site: https://search.jamas.or.jp/link/ui/2016220164
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed