Effects of Hepatoprotective Compounds from the Leaves of Lumnitzera racemosa on Acetaminophen-Induced Liver Damage in Vitro

• Darwish Ahmed Gomaa Gomaa

  Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University Department of Biochemistry, Faculty of Agriculture, Minia University

• Samy Mamdouh Nabil

  Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University Department of Pharmacognosy, Faculty of Pharmacy, Minia University

• Sugimoto Sachiko

  Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University

• Otsuka Hideaki

  Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University Department of Natural Products Chemistry, Faculty of Pharmacy, Yasuda Women’s University

• Abdel-Salam Hosni

  Department of Biochemistry, Faculty of Agriculture, Minia University

• Matsunami Katsuyoshi

  Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University

書誌事項

タイトル別名

• Effects of Hepatoprotective Compounds from the Leaves of <i>Lumnitzera racemosa</i> on Acetaminophen-Induced Liver Damage <i>in Vitro</i>

抄録

Phytochemical investigation of the n-BuOH fraction of the mangrove plant Lumnitzera racemosa WILLD. (Combretaceae) led to the isolation of one new flavonoid glycoside; myrcetin 3-O-methyl glucuronate (1), one new phenolic glycoside; lumniracemoside (2) and one new aliphatic alcohol glycoside; n-hexanol 1-O-rutinoside (3), in addition to seven known compounds (4–10). The structures of these compounds were determined by spectroscopic analyses (UV, IR, high resolution-electrospray ionization (HR-ESI)-MS, one- and two-dimensional (1D- and 2D)-NMR). Compound 7 showed the highest hepatoprotective activity against acetaminophen-induced hepatotoxicity using human HepG2 cells at protection % value of 34.2±3.1%, while compounds 1, 2, 3, 6, and 9 showed weak to moderate hepatoprotective activity (11.6–18.9%). Almost all of these compounds showed stronger 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity compared with the standard Trolox. These results suggest the usefulness of this plant extract and the isolated compounds as promising hepatoprotective agents.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 64 (4), 360-365, 2016

  公益社団法人 日本薬学会

キーワード

• <i>Lumnitzera racemosa</i>
• Combretaceae
• hepatoprotective
• 1,1-diphenyl-2-picrylhydrazyl (DPPH)

詳細情報

• CRID: 1390001204176881280
• NII論文ID: 130005141022
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.c15-00830
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 027220875
• PubMed: 27039833
• Web Site: http://id.ndl.go.jp/bib/027220875
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027220875
• Web Site: https://www.jstage.jst.go.jp/article/cpb/64/4/64_c15-00830/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016347157
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可