Isoflurane-induced postconditioning via mitochondrial calcium-activated potassium channels

• Kinoshita Michiko

  Department of Anesthesiology, Tokushima University Hospital

• M. Tsutsumi Yasuo

  Department of Anesthesiology, Institute of Biomedical Sciences, Tokushima University Graduate School

• Fukuta Kohei

  Department of Anesthesiology, Tokushima University Hospital

• Kasai Asuka

  Department of Anesthesiology, Tokushima University Hospital

• Tanaka Katsuya

  Department of Anesthesiology, Institute of Biomedical Sciences, Tokushima University Graduate School

抄録

Purpose: Activation of the mitochondrial calcium-activated potassium (mK_Ca) channel reportedly confers resistance to myocardial ischemic stress. However, the role of the mK_Ca channel in postconditioning induced by volatile anesthetic remains unclear. Methods: Male Japanese white rabbits underwent coronary artery occlusion for 30 min followed by reperfusion for 3 h. Volatile anesthetic, isoflurane, was administered at 3 min prior to reperfusion for 5 min. Rabbits were injected with the mK_Ca channel blocker, iberiotoxin, or the mK_Ca channel opener, NS1619, at 8 min prior to reperfusion. Myocardial infarct size and the area at risk (AAR) were measured at the end of the experiment. Results: Isoflurane significantly reduced infarct size (23.0±9.8% of the AAR, P<0.05) compared with the control (44.0±9.1%). Iberiotoxin abolished the cardioprotective impact of isoflurane (43.0±11.6%), while iberiotoxin alone exerted no effect on infarct size (45.0±9.5%). NS1619 and isoflurane/NS1619 both significantly reduced infarct size (21.0±10.3% and 19.0±8.8%, respectively, P<0.05 vs control group), but isoflurane/NS1619 showed no additional benefits compared with isoflurane alone. Conclusion: These results indicate that activation of the mK_Ca channel contribute isoflurane-induced postconditioning. J. Med. Invest. 63: 80-84, February, 2016

収録刊行物

• The Journal of Medical Investigation

  The Journal of Medical Investigation 63 (1.2), 80-84, 2016

  国立大学法人　徳島大学医学部

キーワード

• Mitochondrial calcium-activated potassium channel
• Anesthetic-induced postconditioning
• Isoflurane

詳細情報

• CRID: 1390282679222487680
• NII論文ID: 130005141048
• NII書誌ID: AA11166929
• DOI: 10.2152/jmi.63.80
• ISSN: 13496867
• ISSN: 13431420
• PubMed: 27040058
• Web Site: https://www.jstage.jst.go.jp/article/jmi/63/1.2/63_80/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017035235
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • PubMed
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