Quantification of neuropathological findings by image data for the diagnosis of dementia in forensic autopsy cases

  • Takayama Mio
    Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
  • Kashiwagi Masayuki
    Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
  • Matsusue Aya
    Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
  • Waters Brian
    Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
  • Hara Kenji
    Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
  • Ikematsu Natsuki
    Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
  • Kubo Shin-ichi
    Department of Forensic Medicine, Faculty of Medicine, Fukuoka University

この論文をさがす

抄録

The aim of the present study was to quantify neuropathological findings using image analysis software for the diagnosis of dementia in deceased who underwent forensic autopsy. Of the autopsies performed within 48 hours of death and excluding those of patients with head injury, thermal injury, heat stroke, or intracranial lesions, 8 were of autopsy cases clinically diagnosed with dementia and thus included in the dementia group (D). The non-dementia group (non-D) consisted of 6 deceased without dementia. To compare the D and non-D groups, 6 regions and 7 types of pathological findings were observed semi-quantitatively using 4 conventional stainings. Quantitative analysis of collected image data was performed using image analysis software. Semiquantitative analysis of senile plaques and neurofibrillary tangles was performed with Bielschowsky-Hirano's silver staining image data. An easy, simple, and effective quantification method of the pathological findings was achieved. However, no significant differences were observed between the two groups, and diagnosis of dementia by the quantification of pathological findings was not successful. Diagnosis of dementia using image data may be possible in future studies with an increased number of autopsies, and by utilizing staining techniques with higher specificity and sensitivity, such as immunohistochemical staining. J. Med. Invest. 63: 114-118, February, 2016

収録刊行物

参考文献 (11)*注記

もっと見る

関連プロジェクト

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ