IL-6と癌細胞活性  [in Japanese] Interleukin-6 affects cancer cell biology  [in Japanese]

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Author(s)

    • 西野 宏 Nishino Hiroshi
    • 自治医科大学医学部耳鼻咽喉科学講座 Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Jichi Medical University

Abstract

Interleukin-6(IL-6)は代表的な炎症性サイトカインである。IL-6は炎症のみならず癌細胞の生物学的活性に影響を与える。細胞増殖,細胞死抵抗性,浸潤,血管新生,転移,免疫,幹細胞,悪液質に関与していることがわかってきた。IL-6は多くの癌細胞において癌細胞活性を高め,腫瘍形成と転移に関与する重要なサイトカインである。この総説では簡潔にその働きを述べる。

Interleukin-6 (IL-6) is representative typical inflammatory cytokines. IL-6 is now recognized as important mediators linking inflamation and cancer cell biology. Il-6 affects cell proliferation, resistance for apoptosis, invasion, angiogenesis, metastasis, immunity, stem cell, and cachexia. IL-6 is highly up-regulated in many cancers and considered as one of the most important cytokine families during tumorigenesis and metastasis. This review discusses a mechanisms of IL-6 cytokine to tumorigenesis and metastasis.

Journal

  • Journal of Japan Society of Immunology & Allergology in Otolaryngology

    Journal of Japan Society of Immunology & Allergology in Otolaryngology 34(1), 13-18, 2016

    JAPAN SOCIETY OF IMMUNOLOGY AND ALLERGOLOGY IN OTOLARYNGOLOGY

Codes

  • NII Article ID (NAID)
    130005141311
  • Text Lang
    JPN
  • ISSN
    0913-0691
  • Data Source
    J-STAGE 
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