Circulating galectin-3 correlates with angiogenetic factors, indicators of nutritional condition and systemic inflammation in patients with thyroid cancer

• Shimura Tatsuo

  Department of Cancer Biology and Electronics, Fukushima Medical University

• Shibata Masahiko

  Department of Gastrointestinal Oncology, Saitama Medical University International Medical Center

• Gonda Kenji

  Department of Gastrointestinal Oncology, Saitama Medical University International Medical Center

• Nakajima Takahiro

  Department of Organ Regulatory Surgery, Fukushima Medical University

• Chida Shun

  Department of Organ Regulatory Surgery, Fukushima Medical University

• Noda Masaru

  Department of Organ Regulatory Surgery, Fukushima Medical University

• Suzuki Satoshi

  Department of Thyroid and Endocrinology, Fukushima Medical University

• Nakamura Izumi

  Department of Thyroid and Endocrinology, Fukushima Medical University

• Nakano Keiichi

  Department of Thyroid and Endocrinology, Fukushima Medical University

• Fukushima Toshihiko

  Department of Thyroid and Endocrinology, Fukushima Medical University

• Suzuki Shinichi

  Department of Thyroid and Endocrinology, Fukushima Medical University

• Takenoshita Seiichi

  Department of Organ Regulatory Surgery, Fukushima Medical University

Abstract

Background and Aims: Several investigators have reported the significance of circulating galectin-3 in thyroid cancer patients. However, the precise meaning of circulating galectin-3 remains unclear. The aim of this study was to investigate the relationships between serum galectin-3 levels and angiogenetic factors, and nutritional and inflammatory indicators in patients with thyroid cancer. <br>Materials and Methods: Sixty-one patients with thyroid tumors were enrolled, comprising 47 pre-treatment thyroid cancer patients and 14 patients with benign thyroid diseases. Galectin-3, interleukin (IL)-6, vascular endothelial growth factor, granulocyte colony-stimulating factor (G-CSF), soluble form of intercellular adhesion molecule-1 (sICAM-1), retinol binding protein, prealbumin, albumin, and transferrin were measured. C-reactive protein (CRP), neutrophil count, lymphocyte count, and neutrophil/lymphocyte ratio (NLR) were also investigated. <br>Results: The amounts of circulating galectin-3 in benign disease and thyroid cancer were significantly higher than those of healthy volunteers (P < 0.001). Analysis of galectin-3 performance in distinguishing malignant disease from benign disease using a receiver operating characteristic curve revealed that the area under the curve was 0.555. There were statistically significant correlations between the circulating amount of galectin-3 and IL6, G-CSF, and sICAM-1. Serum galectin-3 showed statistically significant correlations with albumin, prealbumin, and transferrin. Circulating galectin-3 exhibited strong correlations with CRP, neutrophil count, lymphocyte count, and NLR. <br>Conclusions: Galectin-3 may be one of the key factors in the regulation of angiogenesis, inflammation, and nutrition.

Journal

• Annals of Cancer Research and Therapy

  Annals of Cancer Research and Therapy 24 (1), 35-40, 2016

  The Japanese Society of Strategies for Cancer Research and Therapy

Keywords

• galectin-3
• thyroid cancer
• interleukin (IL)-6
• soluble intercellular adhesion molecule-1 (ICAM-1)
• granulocyte colony-stimulating factor (G-CSG)

Details

• CRID: 1390282680165418368
• NII Article ID: 130005142080
• DOI: 10.4993/acrt.24.35
• ISSN: 18805469
• ISSN: 13446835
• Web Site: https://www.jstage.jst.go.jp/article/acrt/24/1/24_35/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018065491
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed