エピジェネティクスにおけるヒストンアセチル化の新展開新規ヒストン修飾H4K20ac と遺伝子発現、細胞増殖について

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タイトル別名
  • New insights of histone acetylation in epigenetics ‒physiological significance of H4K20ac in gene expression and cell proliferation‒

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抄録

Previously unknown histone H4 acetylation at Lysine 20 (H4K20ac) was intensively investigated. By mass spectrometry analysis, the existence of H4K20ac in mammalian cells was proved. The genome wide analysis by ChIP seq with a next generation sequencer revealed that H4K20ac was accumulated on the promoter region of weakly expressing genes, which is almost opposite to the conventional view of histone acetylation modifi cations. The motif search of H4K20ac suggested that well-known transcriptional repressor, NRSF can bind to H4K20ac distributed area. Furtherly, gene ontology identifi ed that H4K20ac was implicated in cell growth. New histone acetylation modifi cation, H4K20ac may open new mechanistic insight for cell growth.

収録刊行物

  • Organ Biology

    Organ Biology 22 (2), 181-183, 2015

    一般社団法人　日本臓器保存生物医学会

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