ペプシノゲン法によって判定した萎縮性胃炎の背景因子の検討  [in Japanese] Lifestyle risk factors for atrophic gastritis diagnosed by the pepsinogen test method  [in Japanese]

<i>Helicobacter pylori</i>感染が萎縮性胃炎を介して胃がんを発生させることは, 周知の知見であるが, 萎縮性胃炎についての生活習慣等の背景要因は十分に検討されていない。<BR>2011～2012年に日本多施設共同コホート研究J-MICC study京都フィールド3に参加した1,894人についてペプシノゲン法によって萎縮性胃炎の有無を判定し, 過去1年間の食習慣を含む生活習慣等の資料の揃った男性419人, 女性861人, 合計1,280名(対象者の67.6％)について萎縮性胃炎の背景要因に関する分析を行った。<BR>年齢, 喫煙状況, アルコール摂取の有無で調整し, ロジスティック回帰分析を行った結果, 男性において牛豚肉摂取, 女性においてヘモグロビン値低値, 受動喫煙がリスク要因, 男性の単変量解析において歯の本数が予防要因として検出されたが, 横断的調査であり今後更に前向き研究として検討していく必要がある。

<i>Helicobacter pylori</i> (<i>H. pylori</i>) infection is the primary cause of atrophic gastritis, which is a major risk factor for the development of gastric cancer. This study aimed to reveal the relationship between atrophic gastritis and lifestyle factors. Data for analysis were obtained from a baseline survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in the Kyoto area. Eligible subjects were individuals who were 35 to 69 years old and who participated in a self-administered questionnaire survey including lifestyle factors and in a health check-up between 2011 and 2012. The inclusion criteria of this study were as follows: those who had no history of upper gastrointestinal surgery, upper gastrointestinal disease treatment, and renal failure. Of the 1,894 individuals who participated in the J-MICC Study in Kyoto during the study period, 1,280 (67.6%) were included in this analysis (419 men and 861 women). Atrophic gastritis was diagnosed by the pepsinogen (PG) test method: serum PG I level (≤70ng/ml) and PG I / PG II ratio (≤3.0). The presence of immunoglobulin G antibodies to <i>H. pylori</i> indicated <i>H. pylori</i> infection. After adjusting for age, H. pylori infection, smoking status, and alcohol consumption, the odds ratio of atrophic gastritis associated with beef and/or pork intake 3 times a week or more frequently was 2.22 in men [95% confidence interval (CI) 1.07 - 4.58]. In women, the odds ratio of atrophic gastritis associated with passive smoking within a year was 2.03 (95% CI 1.02 - 4.03). In conclusion, the results of this study in a Japanese population show a positive association between atrophic gastritis and beef and/or pork intake more than 3 times a week (in men) and passive smoking within a year (in women).