Progress towards development of a platelet transfusion product employing iPS cells

  • SUZUKI Daisuke
    Department of Clinical Application, Center for iPS Cells Research and Application, Kyoto University
  • ETO Koji
    Department of Clinical Application, Center for iPS Cells Research and Application, Kyoto University

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Other Title
  • iPS細胞を用いた血小板製剤開発の現状
  • iPS サイボウ オ モチイタ ケッショウバン セイザイ カイハツ ノ ゲンジョウ

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Abstract

Platelet transfusion is indispensable for current medical treatments of hematological disorders. However, alternative platelet sources are urgently needed due to the inadequate donor blood supply, particularly of HLA/HPA-matched platelets. The advent of ‘iPS cell (iPSC) technology’ was considered in light of this problem, which yielded the idea of iPSC-derived platelet production. The safety of iPSC-derived cell therapy is critical, but platelets can be gamma-irradiated prior to their use. Thus, there is an advantage in terms of clinical application. The remaining developmental aim of the in vitro iPSC-derived platelet generation process is to further scale up industrialized culture and production for the packaging of washed-type platelet concentrates, and a laboratory scale production system has already been optimized in preparation for meeting this goal.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 57 (3), 308-314, 2016

    The Japanese Society of Hematology

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