Progress towards development of a platelet transfusion product employing iPS cells
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- SUZUKI Daisuke
- Department of Clinical Application, Center for iPS Cells Research and Application, Kyoto University
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- ETO Koji
- Department of Clinical Application, Center for iPS Cells Research and Application, Kyoto University
Bibliographic Information
- Other Title
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- iPS細胞を用いた血小板製剤開発の現状
- iPS サイボウ オ モチイタ ケッショウバン セイザイ カイハツ ノ ゲンジョウ
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Abstract
Platelet transfusion is indispensable for current medical treatments of hematological disorders. However, alternative platelet sources are urgently needed due to the inadequate donor blood supply, particularly of HLA/HPA-matched platelets. The advent of ‘iPS cell (iPSC) technology’ was considered in light of this problem, which yielded the idea of iPSC-derived platelet production. The safety of iPSC-derived cell therapy is critical, but platelets can be gamma-irradiated prior to their use. Thus, there is an advantage in terms of clinical application. The remaining developmental aim of the in vitro iPSC-derived platelet generation process is to further scale up industrialized culture and production for the packaging of washed-type platelet concentrates, and a laboratory scale production system has already been optimized in preparation for meeting this goal.
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 57 (3), 308-314, 2016
The Japanese Society of Hematology
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Keywords
Details 詳細情報について
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- CRID
- 1390001205036291200
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- NII Article ID
- 130005145476
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- NII Book ID
- AN00252940
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 027245563
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- PubMed
- 27076243
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed