Diagnostic Performance of a Cadmium-Zinc-Telluride Single-Photon Emission Computed Tomography System With Low-Dose Technetium-99m as Assessed by Fractional Flow Reserve
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- Chikamori Taishiro
- Department of Cardiology, Tokyo Medical University
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- Hida Satoshi
- Department of Cardiology, Tokyo Medical University
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- Tanaka Nobuhiro
- Department of Cardiology, Tokyo Medical University Hachioji Medical Center
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- Igarashi Yuko
- Department of Cardiology, Tokyo Medical University
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- Yamashita Jun
- Department of Cardiology, Tokyo Medical University
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- Shiba Chie
- Department of Cardiology, Tokyo Medical University
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- Murata Naotaka
- Department of Cardiology, Tokyo Medical University
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- Hoshino Kou
- Department of Cardiology, Tokyo Medical University
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- Hokama Yohei
- Department of Cardiology, Tokyo Medical University Hachioji Medical Center
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- Yamashina Akira
- Department of Cardiology, Tokyo Medical University
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Background:Although stress single-photon emission computed tomography (SPECT) using a cadmium-zinc-telluride (CZT) camera facilitates radiation dose reduction, only a few studies have evaluated its diagnostic accuracy in Japanese patients by applying fractional flow reserve (FFR) measurements.Methods and Results:We prospectively evaluated 102 consecutive patients with suspected or known coronary artery disease with a low-dose stress/rest protocol (99mTc radiotracer 185/370 MBq) using CZT SPECT. Within 3 months, coronary angiography was performed and a significant stenosis was defined as ≥90% diameter narrowing on visual estimation, or as a lesion of <90% and ≥ 50% stenosis with FFR ≤0.80. To detect individual coronary stenosis, the respective sensitivity, specificity, and accuracy were 86%, 75%, and 82% for left anterior descending artery stenosis, 76%, 81%, and 79% for left circumflex artery stenosis, and 87%, 92%, and 90% for right coronary artery stenosis. When limited to 92 intermediate stenotic lesions in which FFR was measured, stress SPECT showed 77% sensitivity, 91% specificity, and 84% accuracy, whereas the diagnostic value decreased to 52% sensitivity, 68% specificity, and 58% accuracy based only on visual estimation of ≥75% diameter narrowing.Conclusions:CZT SPECT demonstrated a good diagnostic yield in detecting hemodynamically significant coronary stenoses as assessed by FFR, even when using a low-dose 99mTc protocol with an effective dose ≤5 mSv. (Circ J 2016; 80: 1217–1224)
収録刊行物
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- Circulation Journal
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Circulation Journal 80 (5), 1217-1224, 2016
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205107232768
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- NII論文ID
- 130005147648
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 027270036
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- PubMed
- 27053432
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
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