Angiogenic Factor with G-patch and FHA Domain 1 (AGGF1) Expression in Human Vascular Lesions

DOI Web Site 参考文献12件 オープンアクセス
  • Zhan Maosheng
    Department of Pathology, Osaka University Graduate School of Medicine
  • Hori Yumiko
    Department of Pathology, Osaka University Graduate School of Medicine
  • Wada Naoki
    Department of Pathology, Osaka University Graduate School of Medicine
  • Ikeda Jun-ichiro
    Department of Pathology, Osaka University Graduate School of Medicine
  • Hata Yuuki
    Department of Plastic Surgery, Osaka University Graduate School of Medicine
  • Osuga Keigo
    Department of Radiology, Osaka University Graduate School of Medicine
  • Morii Eiichi
    Department of Pathology, Osaka University Graduate School of Medicine

抄録

Angiogenic factor with G-patch and FHA domain 1 (AGGF1) is a novel angiogenic factor that was first described in Klippel-Trenaunay syndrome, a congenital vascular disease associated with capillary and venous malformations. AGGF1, similar to vascular endothelial growth factor (VEGF), has been shown to promote strong angiogenesis in chick embryos in vivo. Blocking AGGF1 expression prevented vessel formation, which suggests AGGF1 is a potent angiogenic factor linked to vascular malformations. So far, AGGF1 expression studies in human vascular lesions have not been performed. Here, we immunohistochemically investigated AGGF1 expression in venous, arteriovenous or capillary malformations, and infantile or congenital hemangioma. We found that AGGF1 was mostly expressed in endothelial cells with plump morphology. Moreover, the majority of mast cells strongly expressed AGGF1. Notwithstanding our incomplete knowledge of the molecular mechanism of AGGF1 in angiogenesis, our results show for the first time that AGGF1 is expressed in plump endothelial cells and mast cells.

収録刊行物

参考文献 (12)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ