フッ素化合物歯面塗布剤によるチタンの腐食と溶出 [in Japanese] Corrosion of Titanium and Release from Titanium Exposed to Tooth Surface Embrocation of Fluoride Products [in Japanese]
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The purpose of this study was to examine the effects of tooth surface embrocation of fluoride products (TSEF) on titanium surface properties and their effects on gingival tissues. First, titanium discs were totally covered with commercially available TSEFs including 9,000 ppm fluoride (pH 3.5-8.0), then the specimens were incubated for 4 min. The tarnish and surface roughness before and after the incubation with TSEFs were analyzed by color difference meter and surface roughness meter, respectively. Next, the accumulated amount of Ti ions released into gingival tissues from the implant exposed to TSEFs (9,000 ppmF, pH 3.5) was measured using inductively coupled plasma mass spectrometry (ICP) . Moreover, the responses in gingival tissues to released Ti ions and/or Porphyromonas gingivalis-lipopolysaccharide (P.g.-LPS) were measured. There were significant differences in color stability and surface roughness of the titanium surfaces exposed to TSEFs including 9,000 ppm fluoride (pH 3.5-4.0), compared to those of pure water and TSEFs including 9,000 ppm fluoride (pH 6.0-8.0) (ANOVA, <sup>**</sup><i>p</i>＜0.01, <sup>*</sup><i>p</i>＜0.05). More Ti ions were detected in the gingival tissues around the implant after treatment with TSEF including 9,000 ppm fluoride (pH 3.5) than those without the same TSEF (ANOVA, <sup>*</sup><i>p</i>＜0.05), which suggests that the fluoride corroded the implant surface under salivary buffering capacity. The injection of P.g.-LPS in the presence of released Ti ions significantly increased the mRNA expression of chemokine (C-C motif) ligand 2, and receptor activator of nuclear factor-lB ligand, in rat gingival tissues (ANOVA, <sup>**</sup><i>p</i>＜0.01, <sup>*</sup><i>p</i>＜0.05). These data suggest that TSEF of lower pH corroded the Ti surface and its released Ti ions may be partly responsible for the infiltration of monocytes and osteoclast differentiation by increasing the sensitivity of gingival epithelial cells to endotoxin in the oral cavity.
- Journal of Japanese Society of Oral Implantology
Journal of Japanese Society of Oral Implantology 29(1), 12-19, 2016
Japanese Society of Oral Implantology