フッ素化合物歯面塗布剤によるチタンの腐食と溶出  [in Japanese] Corrosion of Titanium and Release from Titanium Exposed to Tooth Surface Embrocation of Fluoride Products  [in Japanese]

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Author(s)

    • 和智 貴紀 WACHI Takanori
    • 九州大学大学院歯学研究院口腔機能修復学講座クラウンブリッジ補綴学分野 Section of Fixed Prosthodontics, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University
    • 首藤 崇裕 SHUTO Takahiro
    • 九州大学大学院歯学研究院口腔機能修復学講座クラウンブリッジ補綴学分野 Section of Fixed Prosthodontics, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University
    • 篠原 義憲 SHINOHARA Yoshinori
    • 九州大学大学院歯学研究院口腔機能修復学講座クラウンブリッジ補綴学分野 Section of Fixed Prosthodontics, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University
    • 的野 良就 MATONO Yoshinari
    • 九州大学大学院歯学研究院口腔機能修復学講座クラウンブリッジ補綴学分野 Section of Fixed Prosthodontics, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University
    • 牧平 清超 MAKIHIRA Seicho
    • 九州大学大学院歯学研究院口腔機能修復学講座クラウンブリッジ補綴学分野 Section of Fixed Prosthodontics, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University

Abstract

The purpose of this study was to examine the effects of tooth surface embrocation of fluoride products (TSEF) on titanium surface properties and their effects on gingival tissues. First, titanium discs were totally covered with commercially available TSEFs including 9,000 ppm fluoride (pH 3.5-8.0), then the specimens were incubated for 4 min. The tarnish and surface roughness before and after the incubation with TSEFs were analyzed by color difference meter and surface roughness meter, respectively. Next, the accumulated amount of Ti ions released into gingival tissues from the implant exposed to TSEFs (9,000 ppmF, pH 3.5) was measured using inductively coupled plasma mass spectrometry (ICP) . Moreover, the responses in gingival tissues to released Ti ions and/or Porphyromonas gingivalis-lipopolysaccharide (P.g.-LPS) were measured. There were significant differences in color stability and surface roughness of the titanium surfaces exposed to TSEFs including 9,000 ppm fluoride (pH 3.5-4.0), compared to those of pure water and TSEFs including 9,000 ppm fluoride (pH 6.0-8.0) (ANOVA, <sup>**</sup><i>p</i><0.01, <sup>*</sup><i>p</i><0.05). More Ti ions were detected in the gingival tissues around the implant after treatment with TSEF including 9,000 ppm fluoride (pH 3.5) than those without the same TSEF (ANOVA, <sup>*</sup><i>p</i><0.05), which suggests that the fluoride corroded the implant surface under salivary buffering capacity. The injection of P.g.-LPS in the presence of released Ti ions significantly increased the mRNA expression of chemokine (C-C motif) ligand 2, and receptor activator of nuclear factor-lB ligand, in rat gingival tissues (ANOVA, <sup>**</sup><i>p</i><0.01, <sup>*</sup><i>p</i><0.05). These data suggest that TSEF of lower pH corroded the Ti surface and its released Ti ions may be partly responsible for the infiltration of monocytes and osteoclast differentiation by increasing the sensitivity of gingival epithelial cells to endotoxin in the oral cavity.

Journal

  • Journal of Japanese Society of Oral Implantology

    Journal of Japanese Society of Oral Implantology 29(1), 12-19, 2016

    Japanese Society of Oral Implantology

Codes

  • NII Article ID (NAID)
    130005150160
  • Text Lang
    JPN
  • ISSN
    0914-6695
  • Data Source
    J-STAGE 
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