The Connection between the Periodicity Incremental Lines of Tooth Dentin and the Secretion Rhythm of Melatonin of the Signaling Molecules of Biological Clock

• MISHIMA Hiroyuki

  Depertment of Medical Hygiene, Kochi Gakuen College, Kochi, Japan

• INOUE Atsuko

  Health Sciences Research Institute, Incorporation, Yokohama, Japan

• KADOTA Rika

  Applied Life Science Course, Kochi Gakuen College, Kochi, Japan

• HATTORI Atsuhiko

  Department of Biology, College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Japan

• SUZUKI Nobuo

  Institute of Nature and Environmental Technology, Kanazawa University, Housu-gun, Japan

• KAKEI Mitsuo

  Division of Oral Anatomy, Meikai University School of Dentistry, Sakado, Japan

• MATUMOTO Takashi

  Deptartment of Laboratory Diagnostic, University Hospital, Nihon University School of Dentistry at Matsudo, Matsudo, Japan

• SATOMURA Kazuto

  Department of Oral Medicine and Stomatology, School of Dental Medicine, Turumi University, Yokohama, Japan

• MIAKE Yasuo

  Depertment of Ultrastructural Science, Oral Health Science Center, Tokyo Dental College, Tokyo, Japan

Bibliographic Information

Other Title

• 象牙質の成長線の周期と体内時計の情報伝達分子のメラトニンの分泌リズムの関連

Abstract

The purpose of the present study is to examine the relationship between the periodicity of incremental lines in dentin of teeth and the role of melatonin. In this experiment, 5- and 6-day, 7- and 8-days after birth SD rats were used. In the low melatonin concentration group, the light staining layer became narrow. In the high melatonin concentration group, this layer disappeared. The number and size of calcospherites in predentin increased in proportion to the concentration of melatonin administered. The new incremental line was confirmed in both the incisor and molar dentin of the melatonin treated groups. In SEM-EDS analysis, Ca and P content were increasing by the melatonin treated group compared with the control group. It is considered that melatonin participates in the formation of incremental lines and the calcification mechanism of the odontoblast. The work was supported by KAKENHI (23592727).

Journal

• Journal of the Japanese Association of Regenerative Dentistry

  Journal of the Japanese Association of Regenerative Dentistry 11 (1), 27-39, 2013

  Japanese Association of Regenerative Dentistry

Keywords

• dentin
• melatonin
• incremental lines
• SEM-EDS
• biological clock

Details

• CRID: 1390282680204064000
• NII Article ID: 130005150558
• DOI: 10.11223/jard.11.27
• ISSN: 18800815
• ISSN: 13489615
• Web Site: https://search.jamas.or.jp/link/ui/2014250210
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed