Biological Response to Nanostructure of Carbon Nanotube/titanium Composite Surfaces

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Author(s)

    • NISHIDA Erika
    • Department of Periodontology and Endodontology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
    • AKASAKA Tsukasa
    • Department of Biomaterials and Bioengineering, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
    • KAWANAMI Masamitsu
    • Department of Periodontology and Endodontology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
    • MIYAJI Hirofumi
    • Department of Periodontology and Endodontology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
    • UMEDA Junko
    • Joining and Welding Research Institute, Osaka University, Ibaraki, Japan
    • TAKITA Hiroko
    • Support Section for Education and Research, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
    • KANAYAMA Izumi
    • Department of Periodontology and Endodontology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
    • TANAKA Saori
    • Department of Periodontology and Endodontology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
    • KATO Akihito
    • Department of Periodontology and Endodontology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
    • FUGETSU Bunshi
    • Nano-Agri Lab, Policy Alternatives Research Institute, The University of Tokyo, Tokyo, Japan.

Abstract

Titanium (Ti) is frequently used as a biomaterial in dental and orthopedic implants and in bone fixation devices. Effective modification of the Ti surface plays a crucial role in improving biocompatibility. Carbon nanotubes (CNTs) are among the most interesting nanomaterials due to their unique properties. In this study, we fabricated CNT-Ti composite surfaces by annealing Ti plates covered by different sized CNTs (Nanocyl NC 7000, 9.5 nm diameter and VGCF-H, 150 nm diameter). The properties of these surfaces were examined by scanning electron microscopy, X-ray diffraction, energy dispersive X-ray spectroscopy, raman spectroscopy, contact angle measurement and osteoblast-like cell seeding. In addition, samples were implanted into the subcutaneous tissue of rats. The three-dimensional nanostructures of CNTs and creation of titanium carbide were evident on the Ti surfaces, suggesting that the CNTs were well-anchored onto the Ti plates. CNT modification promoted desirable cell behavior, including cell spreading and proliferation, especially on the Nanocyl-modified surface. Inflammatory response was rarely observed on the Nanocyl surface, but macrophage-like giant cells were frequently observed on the VGCF-H surface. Therefore, the nanomorphology of narrow diameter CNTs provides a CNT-Ti composite surface with good biocompatibility.

Journal

  • Nano Biomedicine

    Nano Biomedicine 7(1), 11-20, 2015

    Nano Biomedical Society

Codes

  • NII Article ID (NAID)
    130005150626
  • NII NACSIS-CAT ID (NCID)
    AA12510316
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1883-5198
  • Data Source
    IR  J-STAGE 
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